Synthesis, Molecular Modeling and Biological Evaluation of Indeno[1,2-b]quinoxaline Derivatives as Antifungal and Antibacterial Agents | ||
Egyptian Journal of Chemistry | ||
Article 14, Volume 63, Issue 7, July 2020, Pages 2577-2590 PDF (1.7 M) | ||
Document Type: Original Article | ||
DOI: 10.21608/ejchem.2020.21366.2275 | ||
Authors | ||
Hayam A. Abd El salam1; Magda A. El-Bendary2; Medhat Ibrahim3; Fatma A. El-Samahy* 1 | ||
1Green Chemistry Department, Chemical Industrial Research Division, National Research Centre. | ||
2Microbial Chemistry Department, Genetic Engineering and Biotechnology Division, National Research Centre. | ||
3Spectroscopy Department, National Research Centre, 33 El-Bohouth St, Dokki, Giza, Egypt, P.O.12622. | ||
Abstract | ||
The (11H-indeno[1,2-b]quinoxalin-11-ylidene)thiocarbohydrazonewere synthesized and consequently some new novel structures were obtained in a good yields. Their chemical structures were assigned by means of spectral analysis. Molecular modeling at B3LYP/6-31 g (d, p) is utilized to calculate both the optimized structure and vibrational spectra of some studied structures. A promising antimicrobial result was obtained from the new synthesized compounds. | ||
Keywords | ||
11Н-Indeno [1; 2-b]quinoxalin-2-one; Thiocarbohydrazides; 2- Chloroacetamide derivatives; Molecular modeling; antimicrobial activity | ||
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