Abnormalities Of Chromosome 17 In Patients With Myeloid Malignancies.
Easa, M., Shawky, N., Al-Azizi, N., Haggag, R. (2022). Abnormalities Of Chromosome 17 In Patients With Myeloid Malignancies.. EKB Journal Management System, 28(5), 999-1008. doi: 10.21608/zumj.2020.20514.1638
Manal Mohammad Easa; Nagwa Mohammad Shawky; Nashwa Mohammad Al-Azizi; rasha Haggag. "Abnormalities Of Chromosome 17 In Patients With Myeloid Malignancies.". EKB Journal Management System, 28, 5, 2022, 999-1008. doi: 10.21608/zumj.2020.20514.1638
Easa, M., Shawky, N., Al-Azizi, N., Haggag, R. (2022). 'Abnormalities Of Chromosome 17 In Patients With Myeloid Malignancies.', EKB Journal Management System, 28(5), pp. 999-1008. doi: 10.21608/zumj.2020.20514.1638
Easa, M., Shawky, N., Al-Azizi, N., Haggag, R. Abnormalities Of Chromosome 17 In Patients With Myeloid Malignancies.. EKB Journal Management System, 2022; 28(5): 999-1008. doi: 10.21608/zumj.2020.20514.1638

Abnormalities Of Chromosome 17 In Patients With Myeloid Malignancies.

Zagazig University Medical Journal
Article 12, Volume 28, Issue 5, September 2022, Page 999-1008  XML PDF (540.23 K)
Document Type: Original Article
DOI: 10.21608/zumj.2020.20514.1638
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Authors
Manal Mohammad Easa email orcid 1; Nagwa Mohammad Shawky2; Nashwa Mohammad Al-Azizi3; rasha Haggagorcid 4
1assistant lecturer of clinical pathology- faculty of medicine- zagazig university- zagazig- Egypt
2professor of clinical pathology, faculty of medicine, zagazig university
3professor of clinical pathology, faculty of medicine - Zagazig university, Zagazig, Egypt
4associate professor of medical oncology dep, zagazig university, zagazig, Egypt
Abstract
Abstract
Background: chromosome 17 abnormalities are non-random cytogenetic events that occur in hematological and myeloid malignancies. Their prognostic impact is mostly related to alteration of tumor suppressor gene p53 by deletion or mutation. The aim of this study is to detect the frequency and types of chromosome 17 abnormalities and their prognostic effect in myeloid malignancies patients.
Methods: the study included 50 patients of newly diagnosed myeloid malignancies divided into three groups: group 1 included 28 AML patients, group 2 included 7 MDS patients and group 3 included 15 CML patients. All studied patients groups were subjected to history taking, clinical examination, routine laboratory investigations, conventional cytogenetic analysis and FISH for detection of chromosome 17 abnormalities.
Results: Chromosome 17 abnormalities were positive in 52% of myeloid malignancies patients; structural abnormalities were more frequent (40%) than numerical abnormalities (12%). Chromosome 17 abnormalities was detected in 67.9% of AML patients, 28.6% of MDS patients, and in 33.3% of CML patients.
Conclusion: Chromosome 17 abnormalities were frequent cytogenetic events that occur in various myeloid neoplasms and have poor prognostic impact related to alteration of tumor suppressor gene (p53).
Keywords
Chromosome 17 abnormalities; Acute Myeloid Leukemia; Myelodysplastic syndrome; chronic myeloid leukemia
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