Conductometric determination of Betahistine dihydrochloride and Heptaminol hydrochloride using silver nitrate | ||||
| Zagazig Journal of Pharmaceutical Sciences | ||||
| Article 1, Volume 28, Issue 2, December 2019, Page 1-9 PDF (1.09 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zjps.2019.17322.1002 | ||||
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| Authors | ||||
Magda M Ayad1; Mervat M Hosny1; Omar M Elabassy  2; Fathalla Belal3
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| 1Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig,Egypt | ||||
| 2Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City, Egypt | ||||
| 3Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt | ||||
| Abstract | ||||
| A simple, precise and cost effective conductometric method was developed for determination of betahistine dihydrochloride and heptaminol hydrochloride in pure form and pharmaceutical formulations. The method is based on the precipitation of chloride ions present in cited drugs with silver ions, yielding silver chloride, the conductance of the solution is measured as a function of the volume of titrant. Effect of solvent, reagent concentration, temperature were studied and evaluated. The suggested method was applied for determination of betahistine dihydrochloride and heptaminol hydrochloride in pure forms and pharmaceutical preparations. The described procedure allowed the determination of betahistine dihydrochloride and heptaminol hydrochloride in the range of 2-10mg/ml and 2-13mg /ml respectively.The molar ratio was (2:1),(1:1) (drug:reagent) between betahistine dihydrochloride and heptaminol hydrochloride with silver nitrate respectively. The suggested procedure was applied successfully to the analysis of these drugs in their pharmaceutical formulations, and the results obtained were in agreement with those given by the official methods | ||||
| Keywords | ||||
| Betahistine dihydrochloride; heptaminol hydrochloride; silver nitrate; conductometric method | ||||
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