Synthesis, Spectroscopic Characterization and antimicrobial studies of Mn(II), Co(II), Ni(II), Cr(III) and Fe(III) Melatonin Drug Complexes
Al-Wasidi, A., Naglah, A., Refat, M., El-Megharbel, S., Kalmouch, A., Moustafa, G. (2020). Synthesis, Spectroscopic Characterization and antimicrobial studies of Mn(II), Co(II), Ni(II), Cr(III) and Fe(III) Melatonin Drug Complexes. EKB Journal Management System, 63(4), 1469-1481. doi: 10.21608/ejchem.2020.21193.2263
Asma S. Al-Wasidi; Ahmed M. Naglah; Moamen Refat; Samy M. El-Megharbel; Atef Kalmouch; Gaber Osman Mohamed Moustafa. "Synthesis, Spectroscopic Characterization and antimicrobial studies of Mn(II), Co(II), Ni(II), Cr(III) and Fe(III) Melatonin Drug Complexes". EKB Journal Management System, 63, 4, 2020, 1469-1481. doi: 10.21608/ejchem.2020.21193.2263
Al-Wasidi, A., Naglah, A., Refat, M., El-Megharbel, S., Kalmouch, A., Moustafa, G. (2020). 'Synthesis, Spectroscopic Characterization and antimicrobial studies of Mn(II), Co(II), Ni(II), Cr(III) and Fe(III) Melatonin Drug Complexes', EKB Journal Management System, 63(4), pp. 1469-1481. doi: 10.21608/ejchem.2020.21193.2263
Al-Wasidi, A., Naglah, A., Refat, M., El-Megharbel, S., Kalmouch, A., Moustafa, G. Synthesis, Spectroscopic Characterization and antimicrobial studies of Mn(II), Co(II), Ni(II), Cr(III) and Fe(III) Melatonin Drug Complexes. EKB Journal Management System, 2020; 63(4): 1469-1481. doi: 10.21608/ejchem.2020.21193.2263

Synthesis, Spectroscopic Characterization and antimicrobial studies of Mn(II), Co(II), Ni(II), Cr(III) and Fe(III) Melatonin Drug Complexes

Egyptian Journal of Chemistry
Article 22, Volume 63, Issue 4, April 2020, Page 1469-1481  XML PDF (1.69 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2020.21193.2263
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Authors
Asma S. Al-Wasidi1; Ahmed M. Naglah2; Moamen Refat3; Samy M. El-Megharbel4; Atef Kalmouch2; Gaber Osman Mohamed Moustafa email 5
1Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia
2Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, 12622- Dokki, Cairo, Egypt
3Taif University
4El-Tahreer str 456
5El-Tahreer str 456
Abstract
Synthesis and characterizations of new Mn(II), Co(II), Ni(II), Cr(III) and Fe(III) melatonin drug complexes have been studied. The melatonin ligand act as a monodentate ligand through nitrogen of the deprotonated –NH pyrrole ring. This was confirmed by infrared spectra and microanalytical analysis. The magnetic moments data approved the complexity of Mn(II), Co(III), Ni(III) as a square planar and Cr(III), Fe(III) as an octahedral geometry, respectively. The biological activity of the melatonin free ligand is lower than that of the respected metal complexes. Thus, this indicates that the complexity is more effective than the antimicrobial activities of melatonin ligand.
Keywords
Melatonin drug; Synthesis; Antimicrobial; complexes; ligand
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