KINETIC STUDIES ON THE ALKYLATING ACTIVITY OF CERTAIN NEW CHALCONES OF ACETYLPYRIDINES | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 8, Volume 18, Issue 1, June 1995, Page 49-53 PDF (244.2 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1995.69679 | ||||
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| Author | ||||
| N. A. El-Koussi | ||||
| Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| The synthesis of a number of chalcones derived from acetylpyridines and some p-substituted benzaldehydes has been accomplished. These compounds were evaluated for their alkylating activity by kinetic studies of their reaction with 2-mercaptoethanol. Compounds with electron withdrawing groups in the p-position of benzylidine moiety showed higher activities than compounds with electron donating groups. Quaternization of the pyridine ring decreased activity profoundly. | ||||
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