DRUG RELEASE FROM PLURONIC GELS | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 4, Volume 17, Issue 1, July 1994, Pages 41-48 PDF (405.75 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.1994.69786 | ||
| Author | ||
| Salwa M. Safwat | ||
| Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||
| Abstract | ||
| The release rate of progesterone, dexamethasone, ethinylestradiol and a-methyldopa(MD) was determined in aqueous gels of pluronic surfactants (F-65, F-127, F-123) and the effects of concentration and temperature were investigated. The release of drugs from pluronic F-127 could be described by the diffusional model and the rate-controlling stage in the release process is diffusion of the dispersed drug through the matrix continuum. The release-rate decreased as the concentration of pluronic F-127 increased for both dexamethasone and progesterone; and increased as the molecular weight of the pluronic type increased (F-65 < F-123 < F-127) for ethinylestradiol. While, the release rate of a-methyldopa(MD) dexamethasone and ethinylestradiol decreased as increasing concentration of the drug and increasing the temperature, we found that increasing progesterone concentration and temperature;increased the release rate. | ||
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