TEMAZEPAM--CYCLODEXTRIN AND TEMAZEPAM-MICROCRYSTALLINE CELLULOSE GROUND MIXTURES FORMULATED INTO TABLETS, CAPSULES AND SUPPOSITORIES | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 6, Volume 17, Issue 1, July 1994, Page 57-64 PDF (435.85 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1994.69788 | ||||
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| Authors | ||||
| S. I. Saleh; S. M. Ahmed; M. O. Ahmed | ||||
| Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| Temazepam-b-cyclodextrin and temazepam-microcrystalline cellulose ground mixtures were formulated into tablets, capsules and suppositories. The produced dosage forms were evaluated with regard to their physical properties and dissolution characteristic. Tablets containing temazepam-b-cyclodextrin or temazepam-microcrystalline cellulose ground mixtures showed reasonable physical properties andfaster dissolution characteristics compared to those containing untreated temazepam or ground alone one. Capsules containing Temazepam-b-cyclodextrin or temazepam-microcrystalline cellulose ground mixtures 'showed faster release characteristics compared to those containing untreated temazepam, the ground alone one or the. commercial temazepam capsule form studied. With regard to the-prepared suppositories, Witepsole H 15 gave rise to suppositories with a very slow release whereas, a mixture of PEG 1500 and PEG 400 (9:1 W/W) gave rise to suppositories with very fast release characteristics. | ||||
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