STUDY OF CHARGE-TRANSFER COMPLEXES BETWEEN IODINE AND SOME ANTIDEPRESSANTS
Refaat, I., Abdelmageed, O., Askal, H., Saleh, G. (1994). STUDY OF CHARGE-TRANSFER COMPLEXES BETWEEN IODINE AND SOME ANTIDEPRESSANTS. EKB Journal Management System, 17(1), 87-94. doi: 10.21608/bfsa.1994.69792
Ibrahim H. Refaat; Osama H. Abdelmageed; Hassan F. Askal; Gamal A. Saleh. "STUDY OF CHARGE-TRANSFER COMPLEXES BETWEEN IODINE AND SOME ANTIDEPRESSANTS". EKB Journal Management System, 17, 1, 1994, 87-94. doi: 10.21608/bfsa.1994.69792
Refaat, I., Abdelmageed, O., Askal, H., Saleh, G. (1994). 'STUDY OF CHARGE-TRANSFER COMPLEXES BETWEEN IODINE AND SOME ANTIDEPRESSANTS', EKB Journal Management System, 17(1), pp. 87-94. doi: 10.21608/bfsa.1994.69792
Refaat, I., Abdelmageed, O., Askal, H., Saleh, G. STUDY OF CHARGE-TRANSFER COMPLEXES BETWEEN IODINE AND SOME ANTIDEPRESSANTS. EKB Journal Management System, 1994; 17(1): 87-94. doi: 10.21608/bfsa.1994.69792

STUDY OF CHARGE-TRANSFER COMPLEXES BETWEEN IODINE AND SOME ANTIDEPRESSANTS

Bulletin of Pharmaceutical Sciences Assiut University
Article 10, Volume 17, Issue 1, July 1994, Pages 87-94    PDF (420.01 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1994.69792
Authors
Ibrahim H. Refaat; Osama H. Abdelmageed; Hassan F. Askal; Gamal A. Saleh
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Abstract
Molecular interactions between iodine and various antidepressants are investigated by UV/Vis spectroscopy. Iodine is found to form charge-transfer complexes (CTC) of n-type with these molecules. Beer's law is obeyed in the concentration range 0.5-30 mg/ml for the studied compounds. The values for the formation constants Kc of these iodinated complexes indicate a strong donor-acceptor interaction. These drugs can, therefore, be expected to interfere with thyroid metabolism. In addition, a good correlation between log € and some antidepressant parameters is found.
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