NOVEL STRUCTURAL HYBRIDS OF MESCALINE WITH PCP-ANALOGS: POTENTIAL ANTAGONISTS FOR CENTRAL PCP-RECEPTORS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 2, Volume 17, Issue 2, December 1994, Page 105-112 PDF (421.82 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1994.69795 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| M. F. M. Abdel-Kreem; M. M. El-Semary; N. H. Eshba; R. M. Shafik | ||||
| Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt | ||||
| Abstract | ||||
| The possible involvement of the synclinal conformation of mescaline with phencyclidine (PCP)-receptors has promoted the synthesis of certain novel structural hybrids of mescaline with PCP-analogs. The effect of mescaline and the potential antagonisticactivity of the newly proposed derivatives at central PCP-receptors of albino rat brains will await investigation. The suggested compounds were chemically 1-aryl-1-(3,4,5-trimethoxy; or trihydroxy) phenethylamino; or N-substituted-phenethylamino cycloalkanes. An N-(2-chloroethyl) moiety was, also incorporated into some of the designed analogs for exploration of the possible participation of such alkylating arm to the elicited activity. | ||||
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