SYNTHESIS OF NOVEL SUCCINIMIDES: SPIRO-, AND N-MANNICH BASE DERIVATIVES WITH POTENTIAL ANTICONVULSANT ACTIVITY
Shafik, R., Ibrahim, E., Abdel-Khalek, M., El-Semary, M. (1993). SYNTHESIS OF NOVEL SUCCINIMIDES: SPIRO-, AND N-MANNICH BASE DERIVATIVES WITH POTENTIAL ANTICONVULSANT ACTIVITY. EKB Journal Management System, 16(1), 88-96. doi: 10.21608/bfsa.1993.70032
Ragab M. Shafik; El-Sebai A. Ibrahim; Magdi M. Abdel-Khalek; Mona El-Semary. "SYNTHESIS OF NOVEL SUCCINIMIDES: SPIRO-, AND N-MANNICH BASE DERIVATIVES WITH POTENTIAL ANTICONVULSANT ACTIVITY". EKB Journal Management System, 16, 1, 1993, 88-96. doi: 10.21608/bfsa.1993.70032
Shafik, R., Ibrahim, E., Abdel-Khalek, M., El-Semary, M. (1993). 'SYNTHESIS OF NOVEL SUCCINIMIDES: SPIRO-, AND N-MANNICH BASE DERIVATIVES WITH POTENTIAL ANTICONVULSANT ACTIVITY', EKB Journal Management System, 16(1), pp. 88-96. doi: 10.21608/bfsa.1993.70032
Shafik, R., Ibrahim, E., Abdel-Khalek, M., El-Semary, M. SYNTHESIS OF NOVEL SUCCINIMIDES: SPIRO-, AND N-MANNICH BASE DERIVATIVES WITH POTENTIAL ANTICONVULSANT ACTIVITY. EKB Journal Management System, 1993; 16(1): 88-96. doi: 10.21608/bfsa.1993.70032

SYNTHESIS OF NOVEL SUCCINIMIDES: SPIRO-, AND N-MANNICH BASE DERIVATIVES WITH POTENTIAL ANTICONVULSANT ACTIVITY

Bulletin of Pharmaceutical Sciences Assiut University
Article 9, Volume 16, Issue 1, June 1993, Pages 88-96    PDF (393.69 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1993.70032
Authors
Ragab M. Shafik; El-Sebai A. Ibrahim; Magdi M. Abdel-Khalek; Mona El-Semary
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
Abstract
Several substituted N-aminomethylsuccinimides (I) and 1'-alkyl, or aralkyl Spiro [indolin-2-one-3,3'-pyrrolidine-2',5 -diones1 (III, XVI) were prepared. The pKa values and the anti-MMS activity of some selected members are reported. Compound XVI showed matching protection mode when compared with ethosuximide.
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