1HNMR OF PYRAZOLES: EFFECT OF INTERACTION OF CARBAMOYL GROUP WITH ADJACENT CENTERS ON THE CHEMICAL SHIFTS OF CONCERNED PROTONS
Mohamed, T., Youssef, A., Ahmed, A. (1992). 1HNMR OF PYRAZOLES: EFFECT OF INTERACTION OF CARBAMOYL GROUP WITH ADJACENT CENTERS ON THE CHEMICAL SHIFTS OF CONCERNED PROTONS. EKB Journal Management System, 15(1), 100-105. doi: 10.21608/bfsa.1992.70220
Tarek A. Mohamed; Adel F. Youssef; Abd-El-Hamid N. Ahmed. "1HNMR OF PYRAZOLES: EFFECT OF INTERACTION OF CARBAMOYL GROUP WITH ADJACENT CENTERS ON THE CHEMICAL SHIFTS OF CONCERNED PROTONS". EKB Journal Management System, 15, 1, 1992, 100-105. doi: 10.21608/bfsa.1992.70220
Mohamed, T., Youssef, A., Ahmed, A. (1992). '1HNMR OF PYRAZOLES: EFFECT OF INTERACTION OF CARBAMOYL GROUP WITH ADJACENT CENTERS ON THE CHEMICAL SHIFTS OF CONCERNED PROTONS', EKB Journal Management System, 15(1), pp. 100-105. doi: 10.21608/bfsa.1992.70220
Mohamed, T., Youssef, A., Ahmed, A. 1HNMR OF PYRAZOLES: EFFECT OF INTERACTION OF CARBAMOYL GROUP WITH ADJACENT CENTERS ON THE CHEMICAL SHIFTS OF CONCERNED PROTONS. EKB Journal Management System, 1992; 15(1): 100-105. doi: 10.21608/bfsa.1992.70220

1HNMR OF PYRAZOLES: EFFECT OF INTERACTION OF CARBAMOYL GROUP WITH ADJACENT CENTERS ON THE CHEMICAL SHIFTS OF CONCERNED PROTONS

Bulletin of Pharmaceutical Sciences Assiut University
Article 11, Volume 15, Issue 1, 1992, Pages 100-105    PDF (228.74 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1992.70220
Authors
Tarek A. Mohamed1; Adel F. Youssef1; Abd-El-Hamid N. Ahmed2
1Department of Medicinal Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut 71516, A.R. Egypt
2Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut 71516, A.R. Egypt
Abstract
The 1HNMR of a series of constitutional isomers of dimethylpyrazole carboxamides revealed the contribution of p and/or n-electrons in deshielding protons a- to CONHR group. Intermolecular hydrogen bonding with polar solvent molecules was able to affect more strongly the CONHR proton chemical shift than intramolecular. The observed pattern of d values shown by CONHR proton in the derivative R= C6H11 allowed to assign for it a trans axial conformation. Finally a regression equation was derived to draw a linear relation between the chemical shifts of CONHR protons in both isomers.
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