PREPARATION AND EVALUATION OF SUSTAINED RELEASE ETHYLCELLULOSE ENCAPSULATED ASPIRIN | ||
Bulletin of Pharmaceutical Sciences Assiut University | ||
Article 9, Volume 13, Issue 2, December 1990, Pages 235-246 PDF (626.75 K) | ||
DOI: 10.21608/bfsa.1990.70581 | ||
Authors | ||
S. A. Ibrahim1; H. A. Sayed1; E. Hafez1; A. M. El-Sayed1; S. S. Ali2 | ||
1Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||
2Department of Histology, Faculty of Medicine, Assiut University, Assiut, Egypt | ||
Abstract | ||
Aspirin microcapsules were prepared by the solvent evaporation method. Ethylcellulose was used as the coating material at 18:2, 17:3 and 16:4 core : coat ratios. The prepared microcapsules were separated into sieve fractions. Each fraction was evaluated for drug content and dissolution characteristics. Scaling-up was developed to evaluate the adopted microencapsulation method for large scale production. The adopted method was simple, efficient and reproducible. A prolonged release pattern of the drug was obtained by increasing the coat/core ratio. Larger microcapsules released aspirin at a slower rate than did smaller microcapsules. Scaling-up did not significantly affect the release characteristics of drug from the prepared microcapsules. Histological studies on the Guinea pig gastric mucosa after the oral administration of encapsulated aspirin revealed a lower incidence of this product compared to unencapsulated drug. | ||
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