PREPARATION AND EVALUATION OF SUSTAINED RELEASE ETHYLCELLULOSE ENCAPSULATED ASPIRIN
Ibrahim, S., Sayed, H., Hafez, E., El-Sayed, A., Ali, S. (1990). PREPARATION AND EVALUATION OF SUSTAINED RELEASE ETHYLCELLULOSE ENCAPSULATED ASPIRIN. EKB Journal Management System, 13(2), 235-246. doi: 10.21608/bfsa.1990.70581
S. A. Ibrahim; H. A. Sayed; E. Hafez; A. M. El-Sayed; S. S. Ali. "PREPARATION AND EVALUATION OF SUSTAINED RELEASE ETHYLCELLULOSE ENCAPSULATED ASPIRIN". EKB Journal Management System, 13, 2, 1990, 235-246. doi: 10.21608/bfsa.1990.70581
Ibrahim, S., Sayed, H., Hafez, E., El-Sayed, A., Ali, S. (1990). 'PREPARATION AND EVALUATION OF SUSTAINED RELEASE ETHYLCELLULOSE ENCAPSULATED ASPIRIN', EKB Journal Management System, 13(2), pp. 235-246. doi: 10.21608/bfsa.1990.70581
Ibrahim, S., Sayed, H., Hafez, E., El-Sayed, A., Ali, S. PREPARATION AND EVALUATION OF SUSTAINED RELEASE ETHYLCELLULOSE ENCAPSULATED ASPIRIN. EKB Journal Management System, 1990; 13(2): 235-246. doi: 10.21608/bfsa.1990.70581

PREPARATION AND EVALUATION OF SUSTAINED RELEASE ETHYLCELLULOSE ENCAPSULATED ASPIRIN

Bulletin of Pharmaceutical Sciences Assiut University
Article 9, Volume 13, Issue 2, December 1990, Pages 235-246    PDF (626.75 K)
DOI: 10.21608/bfsa.1990.70581
Authors
S. A. Ibrahim1; H. A. Sayed1; E. Hafez1; A. M. El-Sayed1; S. S. Ali2
1Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
2Department of Histology, Faculty of Medicine, Assiut University, Assiut, Egypt
Abstract
Aspirin microcapsules were prepared by the solvent evaporation method. Ethylcellulose was used as the coating material at 18:2, 17:3 and 16:4 core : coat ratios. The prepared microcapsules were separated into sieve fractions. Each fraction was evaluated for drug content and dissolution characteristics. Scaling-up was developed to evaluate the adopted microencapsulation method for large scale production.
The adopted method was simple, efficient and reproducible. A prolonged release pattern of the drug was obtained by increasing the coat/core ratio. Larger microcapsules released aspirin at a slower rate than did smaller microcapsules. Scaling-up did not significantly affect the release characteristics of drug from the prepared microcapsules. Histological studies on the Guinea pig gastric mucosa after the oral administration of encapsulated aspirin revealed a lower incidence of this product compared to unencapsulated drug.
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