Evaluation of Serum Neurokinin A Level in Alopecia Areata Patients
William, M., El-Taweel, A., Akl, E., El Fallah, A. (2019). Evaluation of Serum Neurokinin A Level in Alopecia Areata Patients. EKB Journal Management System, 36(2), 42-50. doi: 10.21608/bmfj.2020.70684
Marian Nader William; Abd El Aziz El-Taweel; Essam Akl; Asmaa El Fallah. "Evaluation of Serum Neurokinin A Level in Alopecia Areata Patients". EKB Journal Management System, 36, 2, 2019, 42-50. doi: 10.21608/bmfj.2020.70684
William, M., El-Taweel, A., Akl, E., El Fallah, A. (2019). 'Evaluation of Serum Neurokinin A Level in Alopecia Areata Patients', EKB Journal Management System, 36(2), pp. 42-50. doi: 10.21608/bmfj.2020.70684
William, M., El-Taweel, A., Akl, E., El Fallah, A. Evaluation of Serum Neurokinin A Level in Alopecia Areata Patients. EKB Journal Management System, 2019; 36(2): 42-50. doi: 10.21608/bmfj.2020.70684

Evaluation of Serum Neurokinin A Level in Alopecia Areata Patients

Benha Medical Journal
Article 4, Volume 36, Issue 2, February 2019, Pages 42-50    PDF (1.03 M)
Document Type: Original Article
DOI: 10.21608/bmfj.2020.70684
Authors
Marian Nader William1; Abd El Aziz El-Taweel* 2; Essam Akl2; Asmaa El Fallah3
1Dermatology department benha university
2aDepartment of Dermatology, Venerology and Andrology
3department of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Egypt
Abstract
 
Alopecia areata (AA) is a complex autoimmune condition with increase of some pro-inflammatory mediators. The association of the novel neurokinin A with AA is still unclear. Data concerning other inflammatory diseases suggest a possible role of this neurokinin A in the pathophysiology of AA
Aim      
The aim of this work was to evaluate serum level of neurokinin A in patients with AA and the impact of the AA on dermatological life quality index (DLQI) and depression anxiety stress scale (DASS).
Patients and Methods
Neurokinin A concentrations were measured in 50 patients with AA and 30 healthy controls using enzyme-linked immunosorbent assay (ELISA).
Results
The mean serum levels of neurokinin A was higher in patients than controls with significance p value is (<0.001). It was higher in male patients than females with no significance (p= 0.668). It was statistically significant higher in patient with chronic disease (p=0.023). There was statistically significant positive correlation found between serum neurokinin A level and severity of alopecia tool (SALT) score and stress in DASS subscales (as, p= <0.001, p=0.025) respectively
Conclusion
The mean serum levels of neurokinin A was higher in patients than controls with  significance p value. It was statistically significant higher in patient with chronic disease also There was statistically significant positive correlation between serum neurokinin A level and SALT score and stress in DASS subscales.
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