Correlation between Inflammatory Signals and Tumor Associated Macrophages in Oral Squamous Cell Carcinoma | ||
Egyptian Dental Journal | ||
Article 3, Volume 65, Issue 1 - January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), January 2019, Pages 241-252 PDF (2.25 M) | ||
Document Type: Original Article | ||
DOI: 10.21608/edj.2015.71408 | ||
Authors | ||
Sarah Adolf Barsoom1; Houry Moustafa Baghdadi2; Hala A. El-kammar3; Nermeen S Afifi4 | ||
1Teaching Assistant of Oral Pathology, Faculty of Oral and Dental Medicine, Future University in Egypt | ||
2Professor and Head of Oral Pathology Department, Faculty of Dentistry, Ain Shams University | ||
3Lecturer of Oral Pathology, Faculty of Oral and Dental Medicine, Future University in Egypt. | ||
4Lecturer of Oral Pathology, Faculty of Dentistry, Ain Shams University | ||
Abstract | ||
Background: Squamous cell carcinoma grows in a complex and dynamic stroma. This microenvironment provides all the necessary stimuli for tumor viability, growth and invasiveness. COX-2 is upregulated during both inflammation and cancer. CD163, a marker of M2 macrophages (Tumor associated macrophages- TAMs), has been studied in several aggressive tumors. The increased expression of CD163 was associated with a poor overall survival in various cancers. Aims of the Study: The present study aimed to correlate the inflammatory signals presented by COX-2 immunoexpresion with tumor associated macrophages expressing CD163 in different grades of OSCC. Materials and methods: Immunohistochemical expression of COX-2 and CD163 was evaluated in 30 cases of different grades of OSCC. Results: The mean difference between the well-differentiated level and the moderately differentiated level of COX-2 and CD 163 was statistically insignificant, while that between the well- and poorly differentiated and between the moderately and the poorly differentiated were highly statistically significant. Conclusions: inflammatory signals presented by COX-2 immunoexpression and TAM (CD163+ cells) were elevated with increased tumor grade. | ||
Keywords | ||
COX-2; Tumor associated macrophages; CD 163; Squamous cell carcinoma | ||
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