POLYMERIC FILMS AS TOPICAL DRUG DELIVERY SYSTEM FOR ANTIBIOTICS AND LOCAL ANAESTHETICS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 10, Volume 12, Issue 1, June 1989, Page 152-172 PDF (619.86 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1989.71463 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| S. M. Safwat; E. Hafez; H. A. El-Monem; E. A. lbrahim | ||||
| Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| The utilization of cellulose acetate butyrate films as a topical drug delivery system for chloramphenicol and lignocaire hydrochloride was investigated. The effect of plasticizers and drug concentration on the In-Vitro release of drug as well as on the physicomechanical properties of the films have been examined. The drug release data were kinetically studied and were found to follow the diffusion controlled release model. The incorporation of either dimethyl phthalate or diethyl phthalate afforded the optimum rates of release and optimum water vapor transmission rates and exhibited acceptable mechanical properties. The release rate of chloramphenicol was found markedly higher than that of lignocaine hydrochloride. The effect of plasticizers on drug release is more pronounced in case f water insoluble drug than the water soluble one. | ||||
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