SYNTHESES, ANTIMICROBIAL ACTIVITY AND MASS SPECTRAl INVESTIGATION OF SOME NEW THIOHYDANTOIN AND THIAZOLE DERIVATIVES. | ||
| Al-Azhar Journal of Pharmaceutical Sciences | ||
| Article 4, Volume 45, Issue 1 - Serial Number 45, March 2012, Pages 42-55 PDF (531.5 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ajps.2012.7150 | ||
| Author | ||
| haba Abd El Hady | ||
| Chemistry Department, Faculty of Science (For Girls), Al –Azhar University Nasr City, Egypt. | ||
| Abstract | ||
| 5-(p-Tolyl)-2-[(p-tolylethylidene)hydrazino] thiazole (3) and 3-[(p-tolylethylidene )amino]-2-thiohydantoin (6) have been prepared via cyclization of p-methyl acetophenone thiosemicarbazone (2) with p-methylphenacyl bromide and ethyl chloroacetate in presence of fused sodium acetate . Acetylation of 2,3 and 6 with acetic anhydride afforded the corresponding diacetyl derivative(5) and mono acetyl derivatives (4 and 7). Reaction of 2-thiohydantoin (6) with thiophene-2-carboxaldhyde and chloroacetic acid gives 5-(thiophen-2-ylidene)-3-[(p-tolylethylidene)amino] -2-thiohydantoin (8) and 3-[(p- tolylethylidene )amino] -2-thiohydantoin-5-yl acetic acid (10) . The mass spectral fragmentation patterns of some prepared thiazole and 2-thiohydantoin derivatives have been investigated in order to elucidate the structure of the synthesized compounds. The prepared compounds also exhibited antimicrobial activity. | ||
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