UTILITY OF SOME SULPHA DRUGS IN SYNTHESIS OF NEW BIOLOGICALLY ACTIVE HETEROCYCLIC COMPOUNDS : SYNTHESIS AND ANTICANCER ACTIVITY OF SOME NOVEL THIOSEMICARBAZIDE DERIVATIVES | ||
| Al-Azhar Bulletin of Science | ||
| Article 4, Volume 2011, Issue 6, June 2011, Pages 57-68 PDF (145.75 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/absb.2011.7175 | ||
| Authors | ||
| E. M. AHMED* ; N. M. TAHA; N. M. NADY | ||
| Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Cairo, Egypt. | ||
| Abstract | ||
| N-(4-(N-(2,6-dimethoxypyrimidin-4-yl)sulfamoyl)phenyl) hydrazine carbothioamide novel thiosemicarbazide (3) was used as starting material for synthesis of some novel Diacetyl hydrazine-carbothioamide (4), 1,3,4-Thiadiazol (7), 1,2-bis(carbothioamide) (9), 3,5-di-oxopyrazolidine (10), oxo-4,5-dihydropyrazole (11), 3,4-dihy-drophthalazine (15) and 3,6-dioxopiperazine (16).Where we found that, 1,2-bis(carbothioamide) (5), 1,2,4-triazole (6), carbamothioyl formohydrazonate (8) have anticancer activity of drug (s) using (E.A.C). | ||
| Keywords | ||
| SULPHA DRUGS; THIOSEMICARBAZIDE DERIVATIVES | ||
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