SYNTHESIS AND ANTICANCER ACTIVITY OF IMIDAZOLE DERIVATIVES INCORPORATING CHROMENE MOIETY | ||
| Al-Azhar Journal of Pharmaceutical Sciences | ||
| Article 19, Volume 45, Issue 1 - Serial Number 45, March 2012, Pages 312-322 PDF (461.23 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ajps.2012.7244 | ||
| Author | ||
| Nashwa Saleh | ||
| Department of Chemistry, Faculty of Science (Girl’s), Al-Azhar University, Nasr City, Cairo, Egypt | ||
| Abstract | ||
| The oxo-chromene-6-carbaldehyde derivative 1 was used as a starting material for the synthesis of some novel pyrano[3,2-b] xanthene-4,7-dione 2 and chromen-oxazol-5-(4H)-one derivatives 4,5. Furthermore, the oxazolone derivative 4 was used as key intermediates to synthesize some novel imidazol derivatives 6-14. The structures of target compounds were confirmed by elemental analyses and spectral data. All the target compounds were subjected to in-vitro antitumor activity against breast and colon human tumor cell lines (MCF7 and HCT). Most of the screened compounds showed interesting cytotoxic activities compared to a reference drug. | ||
| Keywords | ||
| Chromene; oxazolone; imidazole; antitumor activity | ||
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