SYNTHESIS, REACTIONS AND ANTITUMOR EVALUATION OF SOME POLYCONDENSED THIAZOLOPYRIMIDINE DERIVATIVES | ||||
| Al-Azhar Journal of Pharmaceutical Sciences | ||||
| Article 22, Volume 45, Issue 1 - Serial Number 45, March 2012, Page 352-364 PDF (467.06 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ajps.2012.7247 | ||||
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| Author | ||||
| Nermin El-Seadawy | ||||
| Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt | ||||
| Abstract | ||||
| Some novel thiazolo[3,2-a]pyrimidines, pyrimidino[1',2':3,2]thiazolo[4,5-b] pyridines,pyrimidino[1'',2'':3',2']thiazolo[4',5':2,3]pyrido-[2,3-d]pyrimidines, pyrimidino [1',2':3,2]thiazolo[4,5-d]pyrimidines, pyrimidino[1',2':3,2]thiazolo[4,5-d][1,2,4] triazolo[3,4-b]pyrimidines (2-10) were prepared starting with 2-(arylmethylene) trimethylthiazolo [3,2-a]pyrimidin-3-one(2). Also, some, S-alkylated thiazolo[4,5-d] pyrimidine derivatives were synthesized via reaction of 4-substited-7,7,9-trimethyl-1,3,4-trihydropyrimidino[1',2':3,2]thiazolo[4,5-d]pyrimidin-2-thione (6b) with different reagents. Furthermore, some of the prepared products were selected and tested for activity against HCT116 and MCF-7 (human colon carcinoma and human breast carcinoma). | ||||
| Keywords | ||||
| Antitumor evaluation; thiazolopyrimidines; Triazolopyrimidines | ||||
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