Parenchymal Down Regulation and Enhanced Stromal Expression of Syndecan-1 in Oral Squamous Cell Carcinoma
Essa, A., Attia, M. (2019). Parenchymal Down Regulation and Enhanced Stromal Expression of Syndecan-1 in Oral Squamous Cell Carcinoma. EKB Journal Management System, 65(Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), 1291-1296. doi: 10.21608/edj.2019.72553
Ahmed Abdelaziz Mohamed Essa; Mahmoud Abdelsalam Attia. "Parenchymal Down Regulation and Enhanced Stromal Expression of Syndecan-1 in Oral Squamous Cell Carcinoma". EKB Journal Management System, 65, Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), 2019, 1291-1296. doi: 10.21608/edj.2019.72553
Essa, A., Attia, M. (2019). 'Parenchymal Down Regulation and Enhanced Stromal Expression of Syndecan-1 in Oral Squamous Cell Carcinoma', EKB Journal Management System, 65(Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), pp. 1291-1296. doi: 10.21608/edj.2019.72553
Essa, A., Attia, M. Parenchymal Down Regulation and Enhanced Stromal Expression of Syndecan-1 in Oral Squamous Cell Carcinoma. EKB Journal Management System, 2019; 65(Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)): 1291-1296. doi: 10.21608/edj.2019.72553

Parenchymal Down Regulation and Enhanced Stromal Expression of Syndecan-1 in Oral Squamous Cell Carcinoma

Egyptian Dental Journal
Article 14, Volume 65, Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), April 2019, Page 1291-1296  XML PDF (3.81 MB)
Document Type: Original Article
DOI: 10.21608/edj.2019.72553
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Authors
Ahmed Abdelaziz Mohamed Essa1; Mahmoud Abdelsalam Attia2
1Lecturer of Oral Pathology, Oral Pathology Department, Tanta University, Egypt, Assistant Professor of Oral Pathology, Faculty of Dentistry, Al-Baha University, Kingdom of Saudi Arabia
2Assistant Professor of Oral Pathology, Oral Pathology Department, Faculty of Dental Medicine Al-Azhar University, Egypt, Associate Professor of Oral Pathology, Faculty of Applied Medical Science, Al-Baha University, Kingdom of Saudi Arabia
Abstract
Background and aim: In normal stratified squamous epithelia, syndecan-1 works as cell adhesion molecule, and exhibits an important role in the regulation of cell growth and differentiation during the development. It is recognized as tumor marker with diagnostic and prognostic role in different cancer types. This study was planned to explore the role of syndecan-1 in oral squamous cell carcinoma.
Materials and Methods: Twenty two cases were histologically diagnosed as Oral Squamous Cell Carcinoma (OSCC) that simultaneously contained dysplastic epithelium and carcinoma in situ (CIS) foci. Immunohistochemical staining for syndecan‑1, alpha smooth muscle actin and Ki-67 were done.
Results: Decreased expression of syndecan-1 from normal epithelia to CIS. In OSCC parenchyma, transition from cell membrane localization into cytoplasm was detected. In addition, strong expression of syndecan-1 in stromal fibroblasts was observed.
Conclusion: Decreased expression of syndecan-1 in parenchymal cells together with its appearance in stromal fibroblasts might be used as a reliable tool in oral squamous cell carcinoma early diagnosis.
Keywords
Syndecan-1; parenchymal; stromal; Oral squamous cell carcinoma
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