QUANTITATIVE MOLAR ABSORPTIVITY-STRUCTURE RELATIONSHIPS OF CERTAIN CATECHOLAMINES | ||||
Bulletin of Pharmaceutical Sciences Assiut University | ||||
Article 6, Volume 11, Issue 2, December 1988, Page 235-247 PDF (406.6 K) | ||||
DOI: 10.21608/bfsa.1988.73517 | ||||
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Authors | ||||
A. F. Youssef; M. E. El-Kommos; H. H. Farag | ||||
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
Abstract | ||||
Molar absorptivities of six catecholamines (CA) are determined from their reactions with hydrochloric acid, boric acid molybdic acid, germanium dioxide, iron (II)-citrate and zirconyl chloride. Significant linear correlations are obtained between emax and the number of ligands. emax of most of the (CA) investigated shows a significant correlation with the molecular connectivity indices of the side chains and pka values. A dimeric state is suggested for (CA) in 0.1 N hydrochloric acid medium. | ||||
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