COMPARISON OF DIFFERENT SURGICAL PROTOCOLS IN MANAGEMENT OF MEDICATION-RELATED OSTEONECROSIS OF THE JAW USING PLATELET-RICH FIBRIN AND BONE MORPHOGENETIC PROTEIN-2 | ||
| Egyptian Dental Journal | ||
| Article 20, Volume 63, Issue 2 - April (Oral Surgery), February 2017, Pages 1375-1384 PDF (1015.94 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/edj.2017.74363 | ||
| Authors | ||
| Hesham Fattouh; Mohamed Ashraf | ||
| Lecturer of Oral and Maxillofacial Surgery, Faculty of Oral and Dental Medicine, Cairo University. | ||
| Abstract | ||
| Objectives: The aim of this study is to compare the effect of platelet-rich fibrin (L-PRF) and bone morphogenetic protein-2 (rhBMP-2) in management of medication-related osteonecrosis of jaw (MRONJ). Patients and Methods: Among 35 patients who were diagnosed with MRONJ, 12 patients were treated with L-PRF, 12 patients were treated with rhBMP-2 and 11 patients were treated with both L-PRF and rhBMP-2, evaluation of surgical sites was done for each patient postoperatively at 4 and 16 weeks. Results: At 4 and 16 weeks postoperatively, MRONJ treated with both L-PRF and rhBMP-2 showed favorable outcomes with complete resolution of the lesions than that treated with L-PRF or rhBMP-2 alone. However this difference didn’t reach the level of statistical significance (P=0.42). Conclusion: The simultaneous use of both L-PRF and rhBMP-2 in management of MRONJ is a better treatment modality compared to the single use of each one of them alone. | ||
| Keywords | ||
| Osteonecrosis of the jaw; PRF; rhBMP-2 | ||
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