COLORIMETRIC DETERMINATION OF PHENOTHIAZINE DRUGS. 4- CORRELATION BETWEEN MOLAR ABSORPTIVITY AND F, R AND X PARAMETERS OF RING SUBSTITUENTS | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 2, Volume 10, Issue 2, December 1987, Pages 21-33 PDF (336.01 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.1987.74393 | ||
| Authors | ||
| M. E. El-Kommos; A. F. Youssef | ||
| Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut, Egypt | ||
| Abstract | ||
| Colorimetric determination of phenothiazines with NBS in strong sulfuric acid solution has been previously reported (6, 7). Correlation of log emax with  and 2cv parameters of C-2 and N-10 substituents is highly significant only on absence of vulnerable groups at C-2 position. Log emax of four compounds with the same N-10 side chain was correlated with Á parameters of C-2 substituents irrespective of their vulnerability to the reagents. Correlation equations were used to predict the electronic parameters Á, and sp of –SO2N(CH3)2 from the spectrophotometric reaction model. | ||
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