SELECTIVE SPECTROPHOTOMETRIC DETERMINATION OF LEVODOPA | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 3, Volume 10, Issue 2, December 1987, Pages 34-46 PDF (346.64 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.1987.74394 | ||
| Author | ||
| M. E. El-Kommos | ||
| Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||
| Abstract | ||
| A selective spectrophotometric method is developed for the quantitative determination of levodopa. The proposed method is based on the interaction of levodopa with thiosemicarbazide in an alkaline medium to form a red coloured product. At the maximum absorption of 500 nm, Beer's law is adhered to over the 0-5-8 mg/ml range. Mglar absorptivity of the coloured product is 2.58 x 104. Job's indicates 1:2 ratio of levodopa to thiosemicarbazide. Resulrs of analysis of larodopa tablets by the proposed method agree well with those of U.S.P.XXI. The method is highly selective since a catecholic function with free adjacent positions is required. | ||
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