SELECTIVE SPECTROPHOTOMETRIC DETERMINATION OF LEVODOPA
El-Kommos, M. (1987). SELECTIVE SPECTROPHOTOMETRIC DETERMINATION OF LEVODOPA. EKB Journal Management System, 10(2), 34-46. doi: 10.21608/bfsa.1987.74394
M. E. El-Kommos. "SELECTIVE SPECTROPHOTOMETRIC DETERMINATION OF LEVODOPA". EKB Journal Management System, 10, 2, 1987, 34-46. doi: 10.21608/bfsa.1987.74394
El-Kommos, M. (1987). 'SELECTIVE SPECTROPHOTOMETRIC DETERMINATION OF LEVODOPA', EKB Journal Management System, 10(2), pp. 34-46. doi: 10.21608/bfsa.1987.74394
El-Kommos, M. SELECTIVE SPECTROPHOTOMETRIC DETERMINATION OF LEVODOPA. EKB Journal Management System, 1987; 10(2): 34-46. doi: 10.21608/bfsa.1987.74394

SELECTIVE SPECTROPHOTOMETRIC DETERMINATION OF LEVODOPA

Bulletin of Pharmaceutical Sciences Assiut University
Article 3, Volume 10, Issue 2, December 1987, Page 34-46  XML PDF (346.64 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1987.74394
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Author
M. E. El-Kommos
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Abstract
A selective spectrophotometric method is developed for the quantitative determination of levodopa. The proposed method is based on the interaction of levodopa with thiosemicarbazide in an alkaline medium to form a red coloured product. At the maximum absorption of 500 nm, Beer's law is adhered to over the 0-5-8 mg/ml range. Mglar absorptivity of the coloured product is 2.58 x 104. Job's indicates 1:2 ratio of levodopa to thiosemicarbazide. Resulrs of analysis of larodopa tablets by the proposed method agree well with those of U.S.P.XXI. The method is highly selective since a catecholic function with free adjacent positions is required. 
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