COLORIMETRIC DETERMINATION OF PHENOTHIAZINE DRUGS 3- CORRELATION BETWEEN MOLAR ABSORPTIVITY AND CERTAIN PHYSICOCHEMICAL PARAMETERS OF RING SUBSTITUENTS
El-Shabouri, S., Youssef, A., Mohamed, F., Rageh, A. (1986). COLORIMETRIC DETERMINATION OF PHENOTHIAZINE DRUGS 3- CORRELATION BETWEEN MOLAR ABSORPTIVITY AND CERTAIN PHYSICOCHEMICAL PARAMETERS OF RING SUBSTITUENTS. EKB Journal Management System, 9(1), 137-148. doi: 10.21608/bfsa.1986.74480
S. R. El-Shabouri; A. F. Youssef; F. A. Mohamed; A-M. I. Rageh. "COLORIMETRIC DETERMINATION OF PHENOTHIAZINE DRUGS 3- CORRELATION BETWEEN MOLAR ABSORPTIVITY AND CERTAIN PHYSICOCHEMICAL PARAMETERS OF RING SUBSTITUENTS". EKB Journal Management System, 9, 1, 1986, 137-148. doi: 10.21608/bfsa.1986.74480
El-Shabouri, S., Youssef, A., Mohamed, F., Rageh, A. (1986). 'COLORIMETRIC DETERMINATION OF PHENOTHIAZINE DRUGS 3- CORRELATION BETWEEN MOLAR ABSORPTIVITY AND CERTAIN PHYSICOCHEMICAL PARAMETERS OF RING SUBSTITUENTS', EKB Journal Management System, 9(1), pp. 137-148. doi: 10.21608/bfsa.1986.74480
El-Shabouri, S., Youssef, A., Mohamed, F., Rageh, A. COLORIMETRIC DETERMINATION OF PHENOTHIAZINE DRUGS 3- CORRELATION BETWEEN MOLAR ABSORPTIVITY AND CERTAIN PHYSICOCHEMICAL PARAMETERS OF RING SUBSTITUENTS. EKB Journal Management System, 1986; 9(1): 137-148. doi: 10.21608/bfsa.1986.74480

COLORIMETRIC DETERMINATION OF PHENOTHIAZINE DRUGS 3- CORRELATION BETWEEN MOLAR ABSORPTIVITY AND CERTAIN PHYSICOCHEMICAL PARAMETERS OF RING SUBSTITUENTS

Bulletin of Pharmaceutical Sciences Assiut University
Article 10, Volume 9, Issue 1, June 1986, Pages 137-148    PDF (329.52 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1986.74480
Authors
S. R. El-Shabouri; A. F. Youssef; F. A. Mohamed; A-M. I. Rageh
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut, Egypt
Abstract
The color intensity developed from the reaction of twelve phenothiazine drugs with I3 has been correlated using physicochemical substituent like Hammett constant sp, and molecular connectivity 1Xv. Results indicated a predominant role of electronic parameter in determining color intensity. The bulkiness described by 1Xv played a significant role. However, other parameters of the side chain were also prominent. Working up multiple parametric regression can be used as a reliable tool to predict the sensitivity and scope of the colorimetric method for other phenothiazines.
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