TITRIMETRIC AND SPECTROPHOTOMETRIC DETERMINATION OF MEBENDAZOLE AND FLUBENDAZOLE USING N-BROMOSUCCINIMIDE | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 7, Volume 9, Issue 2, December 1986, Page 92-104 PDF (344.84 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1986.74580 | ||||
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| Authors | ||||
| F. A. Mohamed; M. B. Sidhom; S. A. Hussein | ||||
| Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| Titrimetric and spectrophotometric determination methods are described for mebendazole and flubendazole in dosage forms. The first method depends upon addition of an excess of standard N-bromosuccinimide (NBS) and after the specified time, the residual reagent is determined iodometrically. This procedure permits semi-micro determination (3-30 mg) of the drug. An alternative procedure involves measurement of the colour produced after reaction with N-bromosuccinimide (lmax 465 nm). The stoichiometry of the reaction was studied and found 1:1 for mebendazole- NBS and 1:2 for flubendazole-NBS. The methods were applied successfully for the analysis of either of the two drugs in some formulations. Average recoveries ranging from 98.70±1.64 to 101.94±0.82 for titrimetric and from 97.5 ± 0.65 to 101.30± 0.55 for spectrophotometric methods were obtained. The methods were compared with U.S.P. XX method in case of mebendazole and were found in good agreement. | ||||
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