PREFORMULATION STUDIES ON DIRECTLY COMPRESSED TEMAZEPAM TABLETS
Aboutaleb, A., Abdel Rahman, A., Ahmed, M. (1986). PREFORMULATION STUDIES ON DIRECTLY COMPRESSED TEMAZEPAM TABLETS. EKB Journal Management System, 9(2), 172-186. doi: 10.21608/bfsa.1986.74588
A. E. Aboutaleb; A. A. Abdel Rahman; M. O. Ahmed. "PREFORMULATION STUDIES ON DIRECTLY COMPRESSED TEMAZEPAM TABLETS". EKB Journal Management System, 9, 2, 1986, 172-186. doi: 10.21608/bfsa.1986.74588
Aboutaleb, A., Abdel Rahman, A., Ahmed, M. (1986). 'PREFORMULATION STUDIES ON DIRECTLY COMPRESSED TEMAZEPAM TABLETS', EKB Journal Management System, 9(2), pp. 172-186. doi: 10.21608/bfsa.1986.74588
Aboutaleb, A., Abdel Rahman, A., Ahmed, M. PREFORMULATION STUDIES ON DIRECTLY COMPRESSED TEMAZEPAM TABLETS. EKB Journal Management System, 1986; 9(2): 172-186. doi: 10.21608/bfsa.1986.74588

PREFORMULATION STUDIES ON DIRECTLY COMPRESSED TEMAZEPAM TABLETS

Bulletin of Pharmaceutical Sciences Assiut University
Article 12, Volume 9, Issue 2, December 1986, Pages 172-186    PDF (412.65 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1986.74588
Authors
A. E. Aboutaleb; A. A. Abdel Rahman; M. O. Ahmed
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Abstract
Temazepam, a benzodiazepine derivative, was prepared in directly compressed tablets using Avicel, Anhydrous Lactose (A.H.L.), STA-Rx 1500, Emcompress and Compactrol. It was found that A.H.L. represents the most suitable single vehicle while Avicel : STA-RX 1:1 blend was the most suitable blend for the preparation of temazepam tablets. STA-RX 1500 and its blends with the other used vehicles were shown to give the highest dissolution. The most uniform tablets were produced on using Emcompress alone or as a binary blend with Avicel (1:1) as directly compressible vehicles.
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