Zinc-alpha 2-glycoprotein serum level in Egyptian females with preeclampsia and eclampsia | ||
Evidence Based Women's Health Journal | ||
Article 1, Volume 8, Issue 2, May 2018, Pages 145-155 PDF (687.83 K) | ||
Document Type: Original Article | ||
DOI: 10.21608/ebwhj.2018.7510 | ||
Authors | ||
Abla A. Abou-Zeid1; Eman Saad Nassar2; Manal Shafik Swelem3; Marian Edwar Tawfik* 4 | ||
1Clinical and Chemical Pathology, Faculty of Medicine, AlexandriaUniversity, Egypt | ||
2Obstetrics and Gynecology Department, Faculty of Medicine, Alexandria University, Egypt | ||
3Obstetrics and Gynecology Department, Faculty of Medicine, AlexandriaUniversity, Egypt | ||
4Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Egypt | ||
Abstract | ||
Objective: The aim of this study was to measure serum zinc-α2-glycoprotein (ZAG) in pregnant Egyptian females with preeclampsia and eclampsia and to correlate its levels to biochemical measures of kidney function, lipid and glucose metabolism. Study Design: It was a retrospective study. Patients and Methods: This study measured ZAG levels by enzyme linked immunosorbent assay (ELISA) in pregnant females with preeclampsia (PE) (no. = 40) and eclampsia (no.=20) and were compared to healthy gestational age-matched subjects (no.=20). In addition, the association of ZAG with kidney function, lipid and glucose metabolism was studied. Results: Significant difference was detected on comparing the different groups regarding ZAG levels (p = 0.001). Furthermore, ZAG was positively correlated to systolic blood pressure, urinary protein, fasting insulin and HOMA-IR.After adjusting for other parameters,the association between ZAG and SBP, urinary protein, serum insulin and HOMA-IR remained significant by multivariate linear regression analysis. Conclusion: The study noted that maternal ZAG serum levels are significantly increased in PE | ||
Keywords | ||
Adipokines; Eclampsia; preeclampsia; ZAG | ||
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