ASSESSMENT OF BONE REGENERATION OF CRITICAL SIZE MANDIBULAR DEFECTS USING ADIPOSE DERIVED STEM CELLS: AN EXPERIMENTAL COMPARATIVE STUDY
Arafat, S., Kamel, S., Hossam, A., Sabry, D. (2017). ASSESSMENT OF BONE REGENERATION OF CRITICAL SIZE MANDIBULAR DEFECTS USING ADIPOSE DERIVED STEM CELLS: AN EXPERIMENTAL COMPARATIVE STUDY. EKB Journal Management System, 63(Issue 3 - July (Oral Surgery)), 2235-2246. doi: 10.21608/edj.2017.75755
Shereen Wagdy Arafat; Samah Mohamed Kamel; Ahmed Mohamed Hossam; Dina Sabry. "ASSESSMENT OF BONE REGENERATION OF CRITICAL SIZE MANDIBULAR DEFECTS USING ADIPOSE DERIVED STEM CELLS: AN EXPERIMENTAL COMPARATIVE STUDY". EKB Journal Management System, 63, Issue 3 - July (Oral Surgery), 2017, 2235-2246. doi: 10.21608/edj.2017.75755
Arafat, S., Kamel, S., Hossam, A., Sabry, D. (2017). 'ASSESSMENT OF BONE REGENERATION OF CRITICAL SIZE MANDIBULAR DEFECTS USING ADIPOSE DERIVED STEM CELLS: AN EXPERIMENTAL COMPARATIVE STUDY', EKB Journal Management System, 63(Issue 3 - July (Oral Surgery)), pp. 2235-2246. doi: 10.21608/edj.2017.75755
Arafat, S., Kamel, S., Hossam, A., Sabry, D. ASSESSMENT OF BONE REGENERATION OF CRITICAL SIZE MANDIBULAR DEFECTS USING ADIPOSE DERIVED STEM CELLS: AN EXPERIMENTAL COMPARATIVE STUDY. EKB Journal Management System, 2017; 63(Issue 3 - July (Oral Surgery)): 2235-2246. doi: 10.21608/edj.2017.75755

ASSESSMENT OF BONE REGENERATION OF CRITICAL SIZE MANDIBULAR DEFECTS USING ADIPOSE DERIVED STEM CELLS: AN EXPERIMENTAL COMPARATIVE STUDY

Egyptian Dental Journal
Article 5, Volume 63, Issue 3 - July (Oral Surgery), July 2017, Page 2235-2246  XML PDF (3.76 MB)
Document Type: Original Article
DOI: 10.21608/edj.2017.75755
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Authors
Shereen Wagdy Arafat1; Samah Mohamed Kamel2; Ahmed Mohamed Hossam3; Dina Sabry4
1Lecturer, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, October University of Modern Sciences and Art.
2Lecturer, Department of Oral Biology, Faculty of Dentistry, October University of Modern Sciences and Art.
3Lecturer, Department of Oral Radiology, Faculty of Dentistry, October University of Modern Sciences and Art.
4Professor, Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University
Abstract
Objectives: this study was to assess the effect of adipose derived stem cells on bone regeneration of mandibular defects of rabbits.
Material and methods: Twenty four adult male New Zealand white rabbits were divided into two groups. Group A (control group) in which surgically created critical size mandibular defects were created and left to heal without grafting. Group B (test/stem group) from which adipose tissue was withdrawn and stem cells were processed and then seeded on the gel-foam scaffold to be grafted in the surgically created critical size mandibular defects. The treatment outcome was evaluated at 2, 4, 8 weeks postoperatively both radiographically and histologically. Mineralization ratio was statistically analyzed.
Results: histologic and radiographic evaluation revealed significant (p ≤0.05) enhancement of bone regeneration at test group (A) as compared to control group (B).
Conclusion: the use Adipose derived mesenchymal stem cells proved to be effective for enhancing bone regeneration in mandibular critical-size bone defects.
Keywords
stem cells; adipose tissue; mandibular defects; bone healing
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