INCREASED SALIVARY AND SERUM LEVELS OF IL-33 IN PATIENTS WITH ORAL PEMPHIGUS VULGARIS | ||
| Egyptian Dental Journal | ||
| Article 15, Volume 63, Issue 4 - October (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), October 2017, Pages 3301-3307 PDF (372.75 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/edj.2017.76186 | ||
| Authors | ||
| Gihane Gharib Madkour1; Ibrahim EL Refaie2 | ||
| 1Associate Professor of Oral Medicine, Diagnosis and Periodontology, Faculty of Oral and Dental Medicine, Cairo University, Egypt. | ||
| 2Lecturer of Oral Medicine, Diagnosis and Periodontology, Faculty of Oral and Dental Medicine, Cairo University, Egypt | ||
| Abstract | ||
| Objective: The objective of this study was to investigate salivary and serum levels of IL-33 in oral pemphigus vulgaris patients, before and after corticosteroid therapy, in a trial to elucidate its possible role in the disease pathogenesis. Subjects and Methods: This study included 30 individuals; 15 patients with oral pemphigus vulgaris and 15 healthy controls. Salivary and serum samples were collected from all patients, before and after corticosteroid therapy, and form healthy controls. IL-33 was quantified in all salivary and serum samples utilizing enzyme-linked immunosorbent assay (ELISA). Results: Compared to healthy controls, IL-33 levels were statistically significantly higher in saliva and serum of patients with oral pemphigus vulgaris. Salivary and serum Levels of IL-33 decreased significantly in all patients after corticosteroid therapy. Conclusion: Results of this study suggest that IL-33 may have a key role in oral pemphigus vulgaris pathogenesis. IL-33 may become a new therapeutic target for oral pemphigus vulgaris. | ||
| Keywords | ||
| Oral Pemphigus vulgaris; IL-33; saliva; serum | ||
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