Synthesis, Characterization and Biological Evaluation Studies of 4‐((3‐Formyl‐4‐hydroxyphenyl) diazinyl) ‐N‐(4‐methyloxazol‐2‐yl) Benzene Sulfonamide with Cu(II), Ni (II), Zn(II) and Ag(I) Using a Microwave Irradiation.
El alfy, H., Hassan, A., Khattab, E., Heakal, B. (2018). Synthesis, Characterization and Biological Evaluation Studies of 4‐((3‐Formyl‐4‐hydroxyphenyl) diazinyl) ‐N‐(4‐methyloxazol‐2‐yl) Benzene Sulfonamide with Cu(II), Ni (II), Zn(II) and Ag(I) Using a Microwave Irradiation.. EKB Journal Management System, 61(4), 569-580. doi: 10.21608/ejchem.2018.3679.1305
Hany El alfy; Ali Hassan; Essam Shawky A. E. H Khattab; Bassem H. Heakal. "Synthesis, Characterization and Biological Evaluation Studies of 4‐((3‐Formyl‐4‐hydroxyphenyl) diazinyl) ‐N‐(4‐methyloxazol‐2‐yl) Benzene Sulfonamide with Cu(II), Ni (II), Zn(II) and Ag(I) Using a Microwave Irradiation.". EKB Journal Management System, 61, 4, 2018, 569-580. doi: 10.21608/ejchem.2018.3679.1305
El alfy, H., Hassan, A., Khattab, E., Heakal, B. (2018). 'Synthesis, Characterization and Biological Evaluation Studies of 4‐((3‐Formyl‐4‐hydroxyphenyl) diazinyl) ‐N‐(4‐methyloxazol‐2‐yl) Benzene Sulfonamide with Cu(II), Ni (II), Zn(II) and Ag(I) Using a Microwave Irradiation.', EKB Journal Management System, 61(4), pp. 569-580. doi: 10.21608/ejchem.2018.3679.1305
El alfy, H., Hassan, A., Khattab, E., Heakal, B. Synthesis, Characterization and Biological Evaluation Studies of 4‐((3‐Formyl‐4‐hydroxyphenyl) diazinyl) ‐N‐(4‐methyloxazol‐2‐yl) Benzene Sulfonamide with Cu(II), Ni (II), Zn(II) and Ag(I) Using a Microwave Irradiation.. EKB Journal Management System, 2018; 61(4): 569-580. doi: 10.21608/ejchem.2018.3679.1305

Synthesis, Characterization and Biological Evaluation Studies of 4‐((3‐Formyl‐4‐hydroxyphenyl) diazinyl) ‐N‐(4‐methyloxazol‐2‐yl) Benzene Sulfonamide with Cu(II), Ni (II), Zn(II) and Ag(I) Using a Microwave Irradiation.

Egyptian Journal of Chemistry
Article 1, Volume 61, Issue 4, July and August 2018, Page 569-580  XML PDF (1.02 MB)
Document Type: Review Articles
DOI: 10.21608/ejchem.2018.3679.1305
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Authors
Hany El alfy email orcid 1; Ali Hassan2; Essam Shawky A. E. H Khattab2; Bassem H. Heakal3
1Kahira pharma, Chemistry, Industry Company, Cairo, Egypt./ Branch of Inorganic Chemistry ,Department of Chemistry, Faculty of Science ,Al-Azher University, Cairo, Egypt
2Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City,11884, Cairo, Egypt
3Research Laboratory, Cairo Oil Refining Company, Mostorod, Kaliobia, Egypt.
Abstract
Green chemistry, a novel and simple method have been developed for the synthesis of some a new series of complexes of 4‐((3‐Formyl‐4‐hydroxyphenyl) diazenyl) ‐N‐(4‐methyloxazol‐2‐yl) benzenesulfonamide with the metal salts of Cu(II), Ni(II), Zn(II), and Ag(I)using a microwave irradiation. The structure of these sulfonamide compounds has been investigated by using elemental analysis, FT-IR, 1H NMR, UV-Vis spectrometric methods, magnetic susceptibility, conductivity measurements and thermal studies. These compounds were screened for in-vitro antibacterial activity against staphylococcus aureus and Streptococcus mutans (Gram positive bacteria), Escherichia coli, Pseudomonas aeruginosa and klebsiella (Gram negative bacteria) and for in-vitro antifungal activity against Candida albicans. The results of the antimicrobial activity studies showed that metal complexes have higher activities than parent ligand. Also, ligand displayed potent antioxidant activity.
Keywords
Green chemistry; Sulfonamide derivatives; complexes; Spectral studies; antimicrobial activity; Antioxidant activity
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