Synthesis, Characterization and Biological Evaluation Studies of 4‐((3‐Formyl‐4‐hydroxyphenyl) diazinyl) ‐N‐(4‐methyloxazol‐2‐yl) Benzene Sulfonamide with Cu(II), Ni (II), Zn(II) and Ag(I) Using a Microwave Irradiation. | ||
Egyptian Journal of Chemistry | ||
Article 1, Volume 61, Issue 4, July and August 2018, Pages 569-580 PDF (1.02 M) | ||
Document Type: Review Articles | ||
DOI: 10.21608/ejchem.2018.3679.1305 | ||
Authors | ||
Hany El alfy* 1; Ali Hassan2; Essam Shawky A. E. H Khattab2; Bassem H. Heakal3 | ||
1Kahira pharma, Chemistry, Industry Company, Cairo, Egypt./ Branch of Inorganic Chemistry ,Department of Chemistry, Faculty of Science ,Al-Azher University, Cairo, Egypt | ||
2Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City,11884, Cairo, Egypt | ||
3Research Laboratory, Cairo Oil Refining Company, Mostorod, Kaliobia, Egypt. | ||
Abstract | ||
Green chemistry, a novel and simple method have been developed for the synthesis of some a new series of complexes of 4‐((3‐Formyl‐4‐hydroxyphenyl) diazenyl) ‐N‐(4‐methyloxazol‐2‐yl) benzenesulfonamide with the metal salts of Cu(II), Ni(II), Zn(II), and Ag(I)using a microwave irradiation. The structure of these sulfonamide compounds has been investigated by using elemental analysis, FT-IR, 1H NMR, UV-Vis spectrometric methods, magnetic susceptibility, conductivity measurements and thermal studies. These compounds were screened for in-vitro antibacterial activity against staphylococcus aureus and Streptococcus mutans (Gram positive bacteria), Escherichia coli, Pseudomonas aeruginosa and klebsiella (Gram negative bacteria) and for in-vitro antifungal activity against Candida albicans. The results of the antimicrobial activity studies showed that metal complexes have higher activities than parent ligand. Also, ligand displayed potent antioxidant activity. | ||
Keywords | ||
Green chemistry; Sulfonamide derivatives; complexes; Spectral studies; antimicrobial activity; Antioxidant activity | ||
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