Synthesis and Characterization of a Novel PAA Carrier for Apitoxin of Apis mellifera L. | ||
| Egyptian Academic Journal of Biological Sciences. A, Entomology | ||
| Article 14, Volume 13, Issue 1, March 2020, Pages 155-164 PDF (874.7 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/eajbsa.2020.76598 | ||
| Authors | ||
| Karim O. Deef1; Hanan Helmy2; Emad M. S. Barakat1; Nadia M. Lotfy1; El Gohary E. El Gohary1 | ||
| 1Entomology Department - Faculty of Science – Ain Shams University | ||
| 2Research and Training Center for Vector Control – Ain Shams University | ||
| Abstract | ||
| The current study aimed to characterize a novel bee venom –loaded polyacrylic acid carrier intended for cancer therapy. Honey bee venom was collected by the electric shock method. Poly acrylic acid and venom-loaded polyacrylic acid were prepared using potassium peroxodisulfate as an initiator. Nanoformulation was achieved by emulsion-solvent diffusion. Characterization was achieved by FT-IR, 1H-NMR, TEM, DFED, and UV spectrophotometry. TEM showed that the resultant spherical nanoparticles were either dispersed or in a nodular form and their diameter was 17-210 nm. DFED showed that the resultant nanoparticles did not show crystalline edges. FTIR and 1H-NMR concluded that there was no marked interaction between drug and selected polymer except in the physical encapsulation process. UV spectrophotometry indicated a 95% uniformity of drug content in the resultant nanoparticles. The study concluded that the PAA carrier may be a promising suitable carrier for bee venom. | ||
| Keywords | ||
| polyacrylic acid; Bee venom; Nanoformulation; Characterization | ||
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