Effects of Moringa Oleifera Aqueous Leaf Extract on Submandibular Salivary Glands of Diabetic Albino Rats
El-sharkawy, R., El-kammar, H., Obeid, R., Bdelkhalek, A. (2018). Effects of Moringa Oleifera Aqueous Leaf Extract on Submandibular Salivary Glands of Diabetic Albino Rats. EKB Journal Management System, 64(Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), 1293-1303. doi: 10.21608/edj.2018.77385
Radwa T. El-sharkawy; Hala A. El-kammar; Raneem F. Obeid; Abdelfattah A. Bdelkhalek. "Effects of Moringa Oleifera Aqueous Leaf Extract on Submandibular Salivary Glands of Diabetic Albino Rats". EKB Journal Management System, 64, Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), 2018, 1293-1303. doi: 10.21608/edj.2018.77385
El-sharkawy, R., El-kammar, H., Obeid, R., Bdelkhalek, A. (2018). 'Effects of Moringa Oleifera Aqueous Leaf Extract on Submandibular Salivary Glands of Diabetic Albino Rats', EKB Journal Management System, 64(Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), pp. 1293-1303. doi: 10.21608/edj.2018.77385
El-sharkawy, R., El-kammar, H., Obeid, R., Bdelkhalek, A. Effects of Moringa Oleifera Aqueous Leaf Extract on Submandibular Salivary Glands of Diabetic Albino Rats. EKB Journal Management System, 2018; 64(Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)): 1293-1303. doi: 10.21608/edj.2018.77385

Effects of Moringa Oleifera Aqueous Leaf Extract on Submandibular Salivary Glands of Diabetic Albino Rats

Egyptian Dental Journal
Article 16, Volume 64, Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), April 2018, Pages 1293-1303    PDF (3.74 M)
Document Type: Original Article
DOI: 10.21608/edj.2018.77385
Authors
Radwa T. El-sharkawy1; Hala A. El-kammar2; Raneem F. Obeid2; Abdelfattah A. Bdelkhalek3
1Lecturer of Oral Histology, Faculty of Oral and Dental Medicine, Future University in Egypt
2Lecturer of Oral Pathology, Faculty of Oral and Dental Medicine, Future University in Egypt
3Lecturer of Microbiology, General Science Department, Faculty of Oral and Dental Medicine, Future University in Egypt
Abstract
Moringa Oleifera (MO), also known as the ‘drumstick tree,’ is recognized as a nutritious and cheap source of phytochemicals, that a have a prominent anti-oxidative effect. Salivary gland dysfunction has been frequently reported in diabetic patients. Diabetes is a chronic metabolic disease that has complications mainly resulting from persistent hyperglycemia.
Aim of the study: To Assess the effect of MO aqueous leaf extract on blood glucose levels in diabetic albino rats and its effect on submandibular salivary glands of diabetic albino rats.
Materials and methods: the study comprised three groups; control, diabetic and MO treated groups. The experiment was terminated after fourteen days. The evaluation was performed by measuring the blood glucose levels and weight. Histological evaluation was done by H&E, PAS and IHC for COX-2.
Results: the blood glucose levels and histological signs of diabetic complications were significantly lowered in the MO treated group.
Conclusion: MO is a promising anti-diabetic treatment and may even reverse some of the diabetic complications.
Keywords
COX-2; diabetes; Moringa oleifera; Reactive oxygen species; Submandibular salivary gland
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