Pharmacokinetic profile and some pharmacodynamic aspects of cefquinome in chickens | ||||
| Journal of Veterinary Medical Research | ||||
| Article 5, Volume 19, Issue 2, March 2009, Page 33-37 PDF (194.01 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jvmr.2009.77815 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| A. A. M. El-Gendy; M. A. Tohamy; Abeer M. Radi | ||||
| Deparment of Pharmacology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, Egypt. | ||||
| Abstract | ||||
| The pharmacokinetic profile and some pharmacodynamic aspects of cefquinome were studied after intramuscular (IM) and subcutaneous (SC) administration of a single dose of 2 mg kg-1 b.wt. in chickens. Tissue distribution and residues of cefquinome after repeated IM injection for 5 consecutive days were also estimated. Cefquinome was rapidly absorbed after IM and SC injection as indicated by short half-lives of absorption (t0.s(ab)) of 0.170 and 0.262 h., respectively, while the elimination half-lives (t05(el)) were 3.428 and 25.023 h., respectively. Repeated IM doses of cefquinome (2 mg kg-1 b.wt., once daily) for 5 consecutive days caused no change in serum enzyme activities of ALT and AST, but induced significant increase in serum uric acid concentration after 72 to 120 hours of administration. The withdrawal time of cefquinome from tissue of chickens is 5 days following the last dose. Cefquinome has a wide spectrum of activity against Esherchia coli, Proteus mirabilis and Pseudomonas aeroginosa. | ||||
| Keywords | ||||
| pharmacokinetic; profile; pharmacodynamic; cefquinome; chickens | ||||
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