Immunological and Biochemical Profiles of Tilmicosin in Rabbits
Said, A., Abdel-Alim, A., El-Nabtity, S., Eldin, M., Fadel, M. (2016). Immunological and Biochemical Profiles of Tilmicosin in Rabbits. EKB Journal Management System, 44(1), 48-55. doi: 10.21608/zvjz.2016.7831
Ahmed Said; Abdel-Alim Abdel-Alim; Sameh El-Nabtity; Manal Eldin; Mai Fadel. "Immunological and Biochemical Profiles of Tilmicosin in Rabbits". EKB Journal Management System, 44, 1, 2016, 48-55. doi: 10.21608/zvjz.2016.7831
Said, A., Abdel-Alim, A., El-Nabtity, S., Eldin, M., Fadel, M. (2016). 'Immunological and Biochemical Profiles of Tilmicosin in Rabbits', EKB Journal Management System, 44(1), pp. 48-55. doi: 10.21608/zvjz.2016.7831
Said, A., Abdel-Alim, A., El-Nabtity, S., Eldin, M., Fadel, M. Immunological and Biochemical Profiles of Tilmicosin in Rabbits. EKB Journal Management System, 2016; 44(1): 48-55. doi: 10.21608/zvjz.2016.7831

Immunological and Biochemical Profiles of Tilmicosin in Rabbits

Zagazig Veterinary Journal
Article 6, Volume 44, Issue 1, March 2016, Page 48-55  XML PDF (242.83 K)
Document Type: Original Article
DOI: 10.21608/zvjz.2016.7831
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Authors
Ahmed Said1; Abdel-Alim Abdel-Alim1; Sameh El-Nabtity1; Manal Eldin2; Mai Fadel email 3
1Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt
2Reproduction Research Institute, Al Haram, Giza, Egypt
3Animal Health Research Institute, Dokki, Giza, Egypt
Abstract
 
This study aimed to evaluate the effect of tilmicosin on rabbit immunity after daily subcutaneous (S.C) injection for 3 successive days. Fifteen New Zealand male rabbits were divided into 3 groups; the first group was left as a control, the second was non treated vaccinated against pasteurellosis (1 mL S.C in the skin fold of the back of the rabbit), while, the third was vaccinated and treated by tilmicosin in a dose of 10 mg/kg BW daily for 3 days. Whole blood and serum samples were collected from each rabbit on 1st ,3rd ,9th ,14th ,21st and 28th days post drug administration to determine some immunological and biochemical parameters. Histopathological examination of liver, kidneys and heart of all groups was also carried out. The results revealed that tilmicosin elicited a significant increase in B-lymphocytes, nitric oxide production by macrophages and lysozyme activity of the serum. Meanwhile, the drug had no significant changes on alanine aminotransferase enzyme (ALT) and aspartate aminotransferase enzyme (AST) levels (liver enzymes). On the 21st day ALT showed significant decrease. Moreover; there were no significant changes on urea and creatinine levels (kidney functions) when compared with control group. Histopathological findings of the vaccinated and treated groups showed lesion score from 1st and 2nd degree. It could be concluded that tilmicosin afforded a good effect on rabbits’ immunity without negative effects on liver and kidney functions.
Keywords
tilmicosin; Pasteurollosis; New Zealand Rabbits; Lysozyme activity; lymphocyte; liver enzymes
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