The expression of NF-κB in Calcifying odonto genic cysts (COCs) and Ghost cell odonto genic carcinomas (GCOCs) | ||
| Egyptian Dental Journal | ||
| Article 9, Volume 64, Issue 4 - October (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), October 2018, Pages 3361-3365 PDF (2.58 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/edj.2018.78901 | ||
| Authors | ||
| Omneya R. Ramadan1; , Manal I. Elnouaem2; Sahar M. ElSheikh2 | ||
| 1Lecturer of Oral Pathology, Faculty of Dentistry, University of Alexandria | ||
| 2Professor of Oral Pathology, Faculty of Dentistry, University of Alexandria | ||
| Abstract | ||
| Background: Calcifying odontogenic cysts (COCs) are considered rare odontogenic lesions with a spectrum of behavioral and clinicopathological features. The rare Ghost cell odontogenic carcinoma (GCOC) is the malignant counterpart of (COC). The goal of this work was to study the expression NF-κB in COCs and GCOCs. Methods: NF-κB expression was evaluated in 8 (COCs) and 4 (GCOCs), using immunohistochemical method. Immunostaining was evaluated semi-quantitatively, following to the intensity and extent of staining. Results: B oth cytoplasmic and nuclear and NF-κB immunopositivity were detected in all COC tissues, as well as in GCOC. Conclusion: The expression of NF-κB may represent an important mechanism of tumor development and thus might have a role in the progression of ghost cell lesions. | ||
| Keywords | ||
| Calcifying odontogenic cyst (COC); Nuclear Factor κB; Ghost cell odontogenic carcinoma (GCOC) | ||
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