The Possible Antidiabetic Effects of Ranolazine Versus Glimepiride In STZ-Induced Type 2 Diabetes In Male Wistar Rats | ||
| Medicine Updates | ||
| Article 3, Volume 1, Issue 1 - Serial Number 2682274, April 2020, Pages 9-28 PDF (943.4 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/muj.2020.25106.1007 | ||
| Author | ||
| Shereen Elsaid Elkholy* | ||
| Clinical pharmacology department- faculty of medicine - portsaid university | ||
| Abstract | ||
| Abstract Background: Type 2 diabetes is a major illness that distresses millions of people. The crucial causes of type 2 diabetes are insulin resistance and decreased insulin secretion Objectives: To evaluate the possible effects of ranolazine versus glimepiride on blood glucose levels, HbA1c, nitric oxide and oxidative stress markers in STZ-induced type 2 diabetes in male Wistar rats and their effect on the histopathological picture of the pancreas. Materials and Methods: Forty male Wistar rats were divided into four groups. The normal control group which received saline (1 mg/kg/day) for 5 weeks. The diabetic control group that received saline (1 mg/kg/day) for 5 weeks. The glimepiride-treated group that received glimepiride ((0.1 mg/kg/day)) once daily for 5 weeks and the ranolazine-treated group that received ranolazine (20 mg/kg) twice daily for 5 weeks. Body weight and fasting blood glucose levels were measured weekly for the 5 weeks, then blood samples were attained for several biochemical analysis: lipid profile, HbA1c, and AGEs. Then rats were sacrificed and the pancreatic tissues were attained for oxidative stress markers assessment, and for histopathological examination using hematoxylin and eosin stain. Results: Ranolazine improved diabetes by reducing fasting blood glucose level, HbA1c, and AGEs. Furthermore, it improved the oxidative stress markers, and the histopathological picture of the pancreas. Conclusion: Ranolazine has the potential to become an innovative agent for treating type 2 diabetes patients. | ||
| Keywords | ||
| Diabetes mellitus; STZ; Oxidative stress markers; HbA1c | ||
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