Determination of Flucloxacillin-sodium in Binary Mixture with Ampicillin-trihydrate Using Univariate and Multivariate Spectrophotometric Methods: A Comparative Study | ||
| Journal of Advanced Pharmacy Research | ||
| Article 4, Volume 2, Issue 3, July 2018, Pages 180-190 PDF (914.14 K) | ||
| Document Type: Research Article | ||
| DOI: 10.21608/aprh.2018.2362.1047 | ||
| Authors | ||
| Khalid Abdel-Salam Attia1; Omar Abdel-Aziz2; Nancy Nasef2; Ghada Mohamed* 1 | ||
| 1Department of Pharmaceutical Analytical Chemistry Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt. | ||
| 2Pharmaceutical Analytical Chemistry, Faculty of pharmacy, Ain shams Univeristy | ||
| Abstract | ||
| Objectives: The aim of this study was to develop four simple and accurate spectrophotometric methods for determination of flucloxacillin-sodium in binary mixture with ampicillin-trihydrate without separation. Methods: One of them was a univariate constant center method and the other three methods were multivariate chemometric methods named; Savitsky-Golay filters, continuous wavelet transform of ratio spectra and wavelet transform of first derivative of the ratio spectra. Results: The proposed methods adopted for selective determination of flucloxacillin-sodium and obey Beer’s law in the range (2-20 µg mL-1). Conclusion: The proposed methods were simple, rapid, economic, accurate and precise; they were successfully applied for the determination of flucloxacillin-sodium in pure form and in pharmaceutical preparations. | ||
| Keywords | ||
| Constant center; Continuous wavelet transform; Flucloxacillin-sodium; Multivariate chemometric; Savitsky-Golay filters | ||
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