Determination of Flucloxacillin-sodium in Binary Mixture with Ampicillin-trihydrate Using Univariate and Multivariate Spectrophotometric Methods: A Comparative Study | ||
Journal of Advanced Pharmacy Research | ||
Article 4, Volume 2, Issue 3, July 2018, Pages 180-190 PDF (914.14 K) | ||
Document Type: Research Article | ||
DOI: 10.21608/aprh.2018.2362.1047 | ||
Authors | ||
Khalid Abdel-Salam Attia1; Omar Abdel-Aziz2; Nancy Nasef2; Ghada Mohamed* 1 | ||
1Department of Pharmaceutical Analytical Chemistry Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt. | ||
2Pharmaceutical Analytical Chemistry, Faculty of pharmacy, Ain shams Univeristy | ||
Abstract | ||
Objectives: The aim of this study was to develop four simple and accurate spectrophotometric methods for determination of flucloxacillin-sodium in binary mixture with ampicillin-trihydrate without separation. Methods: One of them was a univariate constant center method and the other three methods were multivariate chemometric methods named; Savitsky-Golay filters, continuous wavelet transform of ratio spectra and wavelet transform of first derivative of the ratio spectra. Results: The proposed methods adopted for selective determination of flucloxacillin-sodium and obey Beer’s law in the range (2-20 µg mL-1). Conclusion: The proposed methods were simple, rapid, economic, accurate and precise; they were successfully applied for the determination of flucloxacillin-sodium in pure form and in pharmaceutical preparations. | ||
Keywords | ||
Constant center; Continuous wavelet transform; Flucloxacillin-sodium; Multivariate chemometric; Savitsky-Golay filters | ||
Statistics Article View: 468 PDF Download: 1,044 |