Application of PVC Membrane and Modified Carbon Nanotubes Paste as Electrochemical Sensors for Potentiometric Determination of Loperamide Hydrochloride | ||
| Journal of Advanced Pharmacy Research | ||
| Article 2, Volume 4, Issue 2, April 2020, Pages 46-55 PDF (535.74 K) | ||
| Document Type: Research Article | ||
| DOI: 10.21608/aprh.2020.24021.1099 | ||
| Authors | ||
| Fathy Salama; Nasr El abasawy; Ahmed El-Olemy; Mohamed Hasan; Mohamed Kamel* | ||
| Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt. | ||
| Abstract | ||
| Objectives: The main purpose of this work is to design a simple, sensitive, accurate and precise potentiometric membrane ion selective electrodes for selective determination of loperamide hydrochloride in bulk powder and in pharmaceutical preparation. Methods: Electrochemical behavior of loperamide hydrochloride were investigated using PVC membrane and modified carbon nanotubes paste sensors. The linearity of this developed method was established in the concentration range of 10-5 - 10-2 M and10-6 - 10-2 M shows a Nernstian slope of 57.38 mV and 58.74 mV for PVC and Carbon paste sensor, respectively. Results: Validation parameters such as specificity, linearity, accuracy, precision, stability, limit of detection were found to be within the acceptance limit as studied according to IUPAC recommendation data. Conclusion: Both sensors are successfully applied for potentiometric determination of loperamide hydrochloride in its pure form and pharmaceutical formulations. | ||
| Keywords | ||
| Ion selective electrodes; Loperamide hydrochloride; Modified carbon nanotubes paste sensor; PVC membrane sensor | ||
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