Value of Insulin-like Growth Factor II m-RNA-Binding Protein 3 (IMP3) Expression in Serous Ovarian Tumors: An immunohistochemical study
Elshahedy, R., Nasr, A., Hegazy, R., Ibrahim, D. (2022). Value of Insulin-like Growth Factor II m-RNA-Binding Protein 3 (IMP3) Expression in Serous Ovarian Tumors: An immunohistochemical study. EKB Journal Management System, 28(6.1), 65-71. doi: 10.21608/zumj.2020.22114.1678
Reham Mostafa Elshahedy; Awatef Naguib Nasr; Raafat Awad Hegazy; Doaa Abdelaziz Ibrahim. "Value of Insulin-like Growth Factor II m-RNA-Binding Protein 3 (IMP3) Expression in Serous Ovarian Tumors: An immunohistochemical study". EKB Journal Management System, 28, 6.1, 2022, 65-71. doi: 10.21608/zumj.2020.22114.1678
Elshahedy, R., Nasr, A., Hegazy, R., Ibrahim, D. (2022). 'Value of Insulin-like Growth Factor II m-RNA-Binding Protein 3 (IMP3) Expression in Serous Ovarian Tumors: An immunohistochemical study', EKB Journal Management System, 28(6.1), pp. 65-71. doi: 10.21608/zumj.2020.22114.1678
Elshahedy, R., Nasr, A., Hegazy, R., Ibrahim, D. Value of Insulin-like Growth Factor II m-RNA-Binding Protein 3 (IMP3) Expression in Serous Ovarian Tumors: An immunohistochemical study. EKB Journal Management System, 2022; 28(6.1): 65-71. doi: 10.21608/zumj.2020.22114.1678

Value of Insulin-like Growth Factor II m-RNA-Binding Protein 3 (IMP3) Expression in Serous Ovarian Tumors: An immunohistochemical study

Zagazig University Medical Journal
Article 10, Volume 28, Issue 6.1, November 2022, Pages 65-71    PDF (506.78 K)
Document Type: Original Article
DOI: 10.21608/zumj.2020.22114.1678
Authors
Reham Mostafa Elshahedy* 1; Awatef Naguib Nasr2; Raafat Awad Hegazy3; Doaa Abdelaziz Ibrahim4
1pathology department, faculty of medicine, Zagaig university
2pathology department, faculty of medicine, Zagazig university
3Pathology department, faculty of medicine, zagazig university
4pathology department, faculty of medicine, zagazig university
Abstract
Background: Ovarian cancer especially the epithelial type, is a major cause of female morbidity and mortality worldwide, so there is a great need for better diagnostic tools that can improve the histological diagnosis and predict the outcome by using immunohistochemical procedures.
Aim of the work: To evaluate the immunohistochemical expression of Insulin-like Growth Factor II m-RNA-binding Protein 3 (IMP3) in benign, borderline and malignant serous ovarian tumors and correlate this expression with some clinicopathological parameters.
Methods: This cross- sectional study was conducted retrospectively on 63 formalin fixed, paraffin embedded tissue blocks of serous ovarian tumors from pathology department, Zagazig University from 2016 to 2019. Immunohistochemical staining using anti- IMP3 antibodies was done using streptavidin-biotin immunoperoxidase technique. The relationship between the staining intensity and percentage of positively stained cells and clinicopathological factors were statistically analyzed.
Results: IMP3 expression was detected in all borderline and 91.4% of malignant cases, 12.5% of benign cases. IMP3 intensity and percentage of positive stained cells were correlated with higher tumor grades and stages (P
Keywords
IMP3; SBTs; ovarian serous carcinomas; immunohistochemistry
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