Design, synthesis and antibacterial activity of N-aryl-3-(arylamino)-5-(((5-substituted furan-2-yl)methylene)amino)-1H-pyrazole-4-carboxamide as Nitrofurantoin® analogues
Hassan, A., O. Moustafa, G., Morsy, N., Abdou, A., Hafez, T. (2020). Design, synthesis and antibacterial activity of N-aryl-3-(arylamino)-5-(((5-substituted furan-2-yl)methylene)amino)-1H-pyrazole-4-carboxamide as Nitrofurantoin® analogues. EKB Journal Management System, 63(11), 4469-4481. doi: 10.21608/ejchem.2020.26158.2525
Ashraf S. Hassan; Gaber O. Moustafa; Nesrin Mahmoud Morsy; Amr M. Abdou; Taghrid S. Hafez. "Design, synthesis and antibacterial activity of N-aryl-3-(arylamino)-5-(((5-substituted furan-2-yl)methylene)amino)-1H-pyrazole-4-carboxamide as Nitrofurantoin® analogues". EKB Journal Management System, 63, 11, 2020, 4469-4481. doi: 10.21608/ejchem.2020.26158.2525
Hassan, A., O. Moustafa, G., Morsy, N., Abdou, A., Hafez, T. (2020). 'Design, synthesis and antibacterial activity of N-aryl-3-(arylamino)-5-(((5-substituted furan-2-yl)methylene)amino)-1H-pyrazole-4-carboxamide as Nitrofurantoin® analogues', EKB Journal Management System, 63(11), pp. 4469-4481. doi: 10.21608/ejchem.2020.26158.2525
Hassan, A., O. Moustafa, G., Morsy, N., Abdou, A., Hafez, T. Design, synthesis and antibacterial activity of N-aryl-3-(arylamino)-5-(((5-substituted furan-2-yl)methylene)amino)-1H-pyrazole-4-carboxamide as Nitrofurantoin® analogues. EKB Journal Management System, 2020; 63(11): 4469-4481. doi: 10.21608/ejchem.2020.26158.2525

Design, synthesis and antibacterial activity of N-aryl-3-(arylamino)-5-(((5-substituted furan-2-yl)methylene)amino)-1H-pyrazole-4-carboxamide as Nitrofurantoin® analogues

Egyptian Journal of Chemistry
Article 27, Volume 63, Issue 11, November 2020, Pages 4469-4481    PDF (483.88 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2020.26158.2525
Authors
Ashraf S. Hassan* 1; Gaber O. Moustafa2; Nesrin Mahmoud Morsy3; Amr M. Abdou4; Taghrid S. Hafez5
1Organometallic and Organometalloid Chemistry Department, National Research Centre, Dokki 12622, Cairo, Egypt
2Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, 12622-Dokki, Cairo, Egypt. Nahda University, New Beni-Sueif City, Postal code (62521), Beni-Sueif, Egypt.
3Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Dokki 12622, Egypt
4Department of Microbiology and Immunology, National Research Centre 12622 Dokki, Giza, Egypt
5Organometallic and Organometalloid Chemistry Department, National Research Centre, Dokki 12622 Cairo, Egypt
Abstract
Nitrofurantoin® is an effective drug and used for treating urinary infectious diseases. A series of nitrofurantoin® analogues bearing furan and pyrazole scaffolds as N-aryl-3-(arylamino)-5-(((5-substituted furan-2-yl)methylene)amino)-1H-pyrazole-4-carboxamide (7a-g and 9a-f) were designed and synthesized by the condensation of 5-aminopyrazole with 5-nitrofuran-2-carbaldehyde (6) or 5-methylfuran-2-carbaldehyde (8) for evaluation of their antibacterial properties against Gram +ve and Gram -ve bacteria then comparing with nitrofurantoin® as standard drug.
Keywords
Furan scaffold; Pyrazole scaffold; 5-Aminopyrazole; Nitrofurantoin® analogues; Antibacterial
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