Assessment of miR-155 in Saliva of Oral Lichen Planus Patients as a Potential Biomarker of Malignant Transformation Before and After Topical Corticosteroid Therapy
Amr, E., Ghalwash, D., Shaker, O. (2020). Assessment of miR-155 in Saliva of Oral Lichen Planus Patients as a Potential Biomarker of Malignant Transformation Before and After Topical Corticosteroid Therapy. EKB Journal Management System, 66(Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), 961-968. doi: 10.21608/edj.2020.23967.1005
Eman Amr; Dalia Ghalwash; Olfat G Shaker. "Assessment of miR-155 in Saliva of Oral Lichen Planus Patients as a Potential Biomarker of Malignant Transformation Before and After Topical Corticosteroid Therapy". EKB Journal Management System, 66, Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), 2020, 961-968. doi: 10.21608/edj.2020.23967.1005
Amr, E., Ghalwash, D., Shaker, O. (2020). 'Assessment of miR-155 in Saliva of Oral Lichen Planus Patients as a Potential Biomarker of Malignant Transformation Before and After Topical Corticosteroid Therapy', EKB Journal Management System, 66(Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), pp. 961-968. doi: 10.21608/edj.2020.23967.1005
Amr, E., Ghalwash, D., Shaker, O. Assessment of miR-155 in Saliva of Oral Lichen Planus Patients as a Potential Biomarker of Malignant Transformation Before and After Topical Corticosteroid Therapy. EKB Journal Management System, 2020; 66(Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)): 961-968. doi: 10.21608/edj.2020.23967.1005

Assessment of miR-155 in Saliva of Oral Lichen Planus Patients as a Potential Biomarker of Malignant Transformation Before and After Topical Corticosteroid Therapy

Egyptian Dental Journal
Article 1, Volume 66, Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), April 2020, Pages 961-968    PDF (546.11 K)
Document Type: Original Article
DOI: 10.21608/edj.2020.23967.1005
Authors
Eman Amr* 1; Dalia Ghalwash2; Olfat G Shaker3
1oral medicine and periodontology department, faculty of dentistry, Cairo university, Egypt
2oral medicine and periodontology, faculty of dentistry, Cairo university, Egypt
3Professor of Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt
Abstract
Background: Immune dysregulation is undoubtedly implicated in the pathogenesis of oral lichen planus (OLP) and considering the importance of miR-155 in the regulation of the immune response the present study is conducted to assess salivary levels of miR-155 in patients with oral lichen planus lesions and compare these levels before and after corticosteroid therapy to explore its possible implication in the pathogenesis OLP. Methods: Thirty patients were enrolled in this study, 15 healthy individuals with normal mucosa as controls and 15 patients diagnosed with atrophic/erosive OLP lesions. Patients were treated with topical corticosteroid. Salivary levels of miR-155 were assessed before and after 4 weeks of topical steroids therapy. Clinical improvement was assessed via VAS score and Thongprasom scale. Results: A significant reduction of miR-155 levels four weeks post treatment was recorded with a value of 55.67%. There was a highly significant direct correlation between miR-155 levels and VAS score. Conclusion: The overexpression of miR-155 in OLP patients before treatment with its obvious reduction four weeks after therapy suggests it could be directly involved in OLP pathogenesis and shedding a light on the potential of miR-155 to act as an innovative therapeutic target for OLP.
Keywords
miR-155; oral lichen planus; pathogenesis
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