Effect of Trigonella, Allium Sativum and Their Mixture on Some Physiological Parameters in Hyperthyroidimic Rats
Mohamed A. Mustafa, *. (2018). Effect of Trigonella, Allium Sativum and Their Mixture on Some Physiological Parameters in Hyperthyroidimic Rats. EKB Journal Management System, 71(4), 3049-3055.
*Eman G.E Helal, Rasha AA El sayed, Sara Ebrahiem, Mohamed A. Mustafa. "Effect of Trigonella, Allium Sativum and Their Mixture on Some Physiological Parameters in Hyperthyroidimic Rats". EKB Journal Management System, 71, 4, 2018, 3049-3055.
Mohamed A. Mustafa, *. (2018). 'Effect of Trigonella, Allium Sativum and Their Mixture on Some Physiological Parameters in Hyperthyroidimic Rats', EKB Journal Management System, 71(4), pp. 3049-3055.
Mohamed A. Mustafa, *. Effect of Trigonella, Allium Sativum and Their Mixture on Some Physiological Parameters in Hyperthyroidimic Rats. EKB Journal Management System, 2018; 71(4): 3049-3055.

Effect of Trigonella, Allium Sativum and Their Mixture on Some Physiological Parameters in Hyperthyroidimic Rats

The Egyptian Journal of Hospital Medicine
Article 27, Volume 71, Issue 4, April 2018, Page 3049-3055  XML PDF (239.97 K)
Document Type: Original Article
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Author
*Eman G.E Helal, Rasha AA El sayed, Sara Ebrahiem, Mohamed A. Mustafaorcid
Department of Zoology, Faculty of Science (Girls), Al-Azhar University, Cairo, Egypt.
Abstract
Background: alterations in the level of hormones including thyroid hormones lead to physiological/ clinical abnormalities. Aim of work: this study aimed to illustrate the protective effect of Trigonella, Allium sativum or their mixture against hyperthyroidism induced by L-thyroxin in male albino rats. Materials and methods:  thirty albino rats were divided randomly into five groups. Group A: healthy rats, Group B: normal rats were subcutaneously injected with 500 µg/kg body weight L-thyroxin once daily for two weeks to induce hyperthyroidism, Group C: hyperthyroid rats received oral dose of 250 µg/kg body weight/day Trigonella extract. Group D: hyperthyroid rats received oral dose of 250 µg/kg body weight/day Allium sativum extract. Group E: hyperthyroid rats received mixture of Trigonella and Allium sativum extract. At the end of the experiment. Blood samples were collected for biochemical analysis. Results: hyperthyroid rats had significant increase (P<0.05) in serum levels of triodothyronine (T3), thyroxin (T4), TG, VLDL, AST,ALP,BUN and uric acid as well as a significant decrease in TSH, LDL, HDL, LDL/HDL and TC, total protein and percentage of body weight  change compared to the normal control group. Oral administration of these extracts ameliorated most of the tested parameters.
Conclusion: This study concluded that Allium sativum, Trigonella or their mixture     have a protective effect against hyperthyroidism 

Keywords
Hyperthyroidism; Trigonella; Allium sativum
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