Vanin-1 Gene Expression in Acne Vulgaris and its Correlation with Disease Severity | ||
| Egyptian Journal of Medical Research | ||
| Article 1, Volume 1, Issue 2, June 2020, Pages 5-11 PDF (691.53 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejmr.2020.89104 | ||
| Authors | ||
| Aya Amin* 1; Abd-ElAziz El-Rifaie2; Laila Ahmed Rashed3; Shaimaa Taha Osman1 | ||
| 1Dermatology Department, Faculty of Medicine, Beni Suef University, Beni Suef, Egypt | ||
| 2Dermatology Department, Faculty of Medicine, Beni Suef University, Beni Suef, Egypt. | ||
| 3Biochemistry department, Faculty of Medicine, Cairo University, Cairo, Egypt | ||
| Abstract | ||
| Background: Acne vulgaris is the most prevalent chronic disease worldwide, occurs during adolescence. The pathogenesis is multifactorial with different grades of severity and the human vanin gene family especially vanin-1 might play a role in pathogenesis of acne. Aim: explore the role of Vanin-1 in acne vulgaris and its correlation with disease severity, duration, weight and residency. Patient and method: 42 acne patients and 42 age and sex matched healthy controls were enrolled. Skin biopsies were taken from the patient and normal skin of controls. Vanin-1 gene expression was estimated by real time PCR. Results: Expression of Vanin-1 gene in acne patients was significantly higher than healthy controls (p-value<0.001), also, there are positive correlation between VNN1 gene expression and patients weight and acne duration (P<0.001), also VNN1 gene expression is significantly higher among urban as compared with rural patients. Conclusion: VNN-1 gene expression is significantly higher in acne patients than healthy controls indicating thatVanin-1 gene involved in pathogenesis of acne vulgaris. In dermatological diseases; Vanin-1 might be a new promising target for therapeutic intervention in acne vulgaris. | ||
| Keywords | ||
| Vanin-1 Gene; Acne Vulgaris; dermatology | ||
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