FORMULATION AND STABILITY OF HEPTAMINOL INJECTABLE SOLUTION | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 2, Volume 7, Issue 2, December 1984, Pages 261-271 PDF (422.7 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.1984.89691 | ||
| Authors | ||
| A. A. Kassem; M. F. El-Miligi; S. A. Ali | ||
| Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt | ||
| Abstract | ||
| The present work consists of a study of formulated aqueous injectable solutions of Heptaminol hydrochloride with respect to their physical and chemical stability as such, under different sterilization conditions, in presence, and in absence of antioxidants and bactericides. It was concluded that chlorocresol was incompatible with Heptaminol hydrochloride giving a pink colour. Also, inclusion of an antioxidant improved the shelf-life of Heptaminol injection. Sodium thiosulphate was regarded the first choice among the stabilizers tested. In addition, it was proved that different heat-sterilization techniques adopted variably influenced the medicament stability depending upon the particular antioxidant in the formula. Market injections were also tested and their stability was found to occupy the first place. | ||
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