CLINICAL SIGNIFICANCE OF SERUM N-TERMINAL PRO C-TYPE NATRIURETIC PEPTIDE IN HEPATITIS C-RELATED CHRONIC LIVER DISEASES
ABDELKADER, N., ZAKI, M., SAAD, W., HAMDY, G., SABRY, D. (2015). CLINICAL SIGNIFICANCE OF SERUM N-TERMINAL PRO C-TYPE NATRIURETIC PEPTIDE IN HEPATITIS C-RELATED CHRONIC LIVER DISEASES. EKB Journal Management System, 45(2), 219-226. doi: 10.21608/jesp.2015.89808
NADIA A. ABDELKADER; MONA ZAKI; WESSAM E. SAAD; GEHAN HAMDY; DINA SABRY. "CLINICAL SIGNIFICANCE OF SERUM N-TERMINAL PRO C-TYPE NATRIURETIC PEPTIDE IN HEPATITIS C-RELATED CHRONIC LIVER DISEASES". EKB Journal Management System, 45, 2, 2015, 219-226. doi: 10.21608/jesp.2015.89808
ABDELKADER, N., ZAKI, M., SAAD, W., HAMDY, G., SABRY, D. (2015). 'CLINICAL SIGNIFICANCE OF SERUM N-TERMINAL PRO C-TYPE NATRIURETIC PEPTIDE IN HEPATITIS C-RELATED CHRONIC LIVER DISEASES', EKB Journal Management System, 45(2), pp. 219-226. doi: 10.21608/jesp.2015.89808
ABDELKADER, N., ZAKI, M., SAAD, W., HAMDY, G., SABRY, D. CLINICAL SIGNIFICANCE OF SERUM N-TERMINAL PRO C-TYPE NATRIURETIC PEPTIDE IN HEPATITIS C-RELATED CHRONIC LIVER DISEASES. EKB Journal Management System, 2015; 45(2): 219-226. doi: 10.21608/jesp.2015.89808

CLINICAL SIGNIFICANCE OF SERUM N-TERMINAL PRO C-TYPE NATRIURETIC PEPTIDE IN HEPATITIS C-RELATED CHRONIC LIVER DISEASES

Journal of the Egyptian Society of Parasitology
Article 1, Volume 45, Issue 2, August 2015, Pages 219-226    PDF (11.32 M)
Document Type: Original Article
DOI: 10.21608/jesp.2015.89808
Authors
NADIA A. ABDELKADER1; MONA ZAKI2; WESSAM E. SAAD2; GEHAN HAMDY3; DINA SABRY4
1of Tropical Medicine, Faculty of Medicine, Ain Shams University; Cairo 11566, Egypt.
2Departments of Clinical and Chemical Pathology, Faculty of Medicine, Ain Shams University; Cairo 11566, Egypt.
3Department of Internal Medicine,Faculty of Medicine, Cairo University, Cairo, Egypt.
4Department of Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt.
Abstract
To evaluate the clinical utility of serum levels of N- terminal pro C- type natriuretic peptide (NT-pro CNP) in patients with hepatitis C related chronic liver disease (CLD), in prospective to disease complications and progression. This study included 66 hepatitis C- related CLD patients with and without ascites and 15 healthy individuals (control group). Serum NT-pro CNP was measured by ELISA. A stepwise progressive increase in NT-pro CNP levels was recorded through controls, patients without ascites and patients with ascites (p< 0.05). In addition, patients with hematemesis or encephalopathy had more than its double values than those without (p<0.01). Moreover, a significant difference was observed in the marker levels among esophageal varcies stages 1, 2, 3 (H=13.679, p=0.001), with highest levels in grade 3. NT-pro CNP correlated positively with alpha fetoprotein (rs =0.455, p=0.008) with no significant correlation neither with MELD nor Child scores (p>0.05). ROC curve analysis revealed the overall performance of the marker in discriminating CLD patients collectively from controls, the optimum cut-off level was 85 ng/L (AUC= 0. 803, sensitivity 84.8%& specificity 53.3%). An increased level of NT-pro CNP is a promising non-invasive marker of hepatitis C related CLD complications and disease
progression.
Keywords
Natriuretic Peptide; NT-pro CNP; Chronic Liver Disease; Hepatitis C
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