Pharmacokinetic of Cefquinome After Single I.V Administration Alone and Concurrent with Meloxicam in Goats
salamah, S., Attia, T., El-Hewaity, M., El Hanbaly, S., El-Gendy, H. (2020). Pharmacokinetic of Cefquinome After Single I.V Administration Alone and Concurrent with Meloxicam in Goats. EKB Journal Management System, 2(1), 101-106. doi: 10.21608/jcvr.2020.90231
soaad salamah; Taha Attia; Mohamed El-Hewaity; Saber El Hanbaly; Hanem El-Gendy. "Pharmacokinetic of Cefquinome After Single I.V Administration Alone and Concurrent with Meloxicam in Goats". EKB Journal Management System, 2, 1, 2020, 101-106. doi: 10.21608/jcvr.2020.90231
salamah, S., Attia, T., El-Hewaity, M., El Hanbaly, S., El-Gendy, H. (2020). 'Pharmacokinetic of Cefquinome After Single I.V Administration Alone and Concurrent with Meloxicam in Goats', EKB Journal Management System, 2(1), pp. 101-106. doi: 10.21608/jcvr.2020.90231
salamah, S., Attia, T., El-Hewaity, M., El Hanbaly, S., El-Gendy, H. Pharmacokinetic of Cefquinome After Single I.V Administration Alone and Concurrent with Meloxicam in Goats. EKB Journal Management System, 2020; 2(1): 101-106. doi: 10.21608/jcvr.2020.90231

Pharmacokinetic of Cefquinome After Single I.V Administration Alone and Concurrent with Meloxicam in Goats

Journal of Current Veterinary Research
Article 12, Volume 2, Issue 1, April 2020, Page 101-106  XML PDF (367.59 K)
Document Type: Original Article
DOI: 10.21608/jcvr.2020.90231
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Authors
soaad salamah email 1; Taha Attia1; Mohamed El-Hewaity2; Saber El Hanbaly1; Hanem El-Gendy1
1Department of Pharmacology, Faculty of Veterinary Medicine, University of Sadat City, Egypt.
2Department of Pharmacology, Faculty of Veterinary Medicine, Menoufia University, Egypt.
Abstract
The active profile of cefquinome in goats was concentrated after single intravenous organization of cefquinome alone and single intravenous organizations in goats pretreated with meloxicam at a portion of 2 mg/kg b.wt. Serum groupings of cefquinome were dictated by utilizing superior fluid chromatography (HPLC). Following compartmental examination, a two-compartment open model best portrayed the fixation time information of cefquinome after i.v. organization The outcomes uncovered that after a solitary intravenous injection, cefquinome was distinguished till 24 hours, dispersion half-life (t1/2á) of cefquinome was 0.281 ± 0.055 h, elimination half-life (t1/2â) was of 5.46 ± 0.22 h and clearance (CL) was 0.04 ± 0.0013 (L/kg/h), volume of distribution at steady state (Vdss) was 0.31 ± 0.018 (L/kg). Following a single intravenous injection pretreated with meloxicam, distribution half-life (t1/2á) was 0.227 ± 0.07 h, elimination half-life (t1/2â) was of 3.63 ± 0.055 h and clearance (CL) was 0.056 ± 0.0022 (L/kg/h), volume of distribution at steady state (Vdss) was 0.296 ± 0.0163 (L/kg). From this examination, we inferred that organization of meloxicam (0.2 mg/kg b.wt.) may be successfully co-administrated with cefquinome (2 mg/kg b.wt.) for combating bacterial infections with an inflammatory condition in goats without any antagonistic effect on the kinetics of cefquinome.

Keywords
Cefquinome; Goats; Meloxicam
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