Changes in intraocular pressure after intravitreal injection of ranibizumab
Fouad, A., SAIF, M., Abd El Hafez, K. (2020). Changes in intraocular pressure after intravitreal injection of ranibizumab. EKB Journal Management System, 3(Geriatric ophthalmology), 23-28. doi: 10.21608/niles.2020.26776.1009
Asmaa Mohamed Fouad; Mohamed Yasser Sayed SAIF; Khaled Abd ElAziz Abd El Hafez. "Changes in intraocular pressure after intravitreal injection of ranibizumab". EKB Journal Management System, 3, Geriatric ophthalmology, 2020, 23-28. doi: 10.21608/niles.2020.26776.1009
Fouad, A., SAIF, M., Abd El Hafez, K. (2020). 'Changes in intraocular pressure after intravitreal injection of ranibizumab', EKB Journal Management System, 3(Geriatric ophthalmology), pp. 23-28. doi: 10.21608/niles.2020.26776.1009
Fouad, A., SAIF, M., Abd El Hafez, K. Changes in intraocular pressure after intravitreal injection of ranibizumab. EKB Journal Management System, 2020; 3(Geriatric ophthalmology): 23-28. doi: 10.21608/niles.2020.26776.1009

Changes in intraocular pressure after intravitreal injection of ranibizumab

NILES journal for Geriatric and Gerontology
Article 4, Volume 3, Geriatric ophthalmology, May 2020, Page 23-28  XML PDF (1.04 MB)
Document Type: Original Article
DOI: 10.21608/niles.2020.26776.1009
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Authors
Asmaa Mohamed Fouad email 1; Mohamed Yasser Sayed SAIForcid 2, 3; Khaled Abd ElAziz Abd El Hafez4
1Faculty of medicine-BeniSuef University BeniSuef
2Ophthalmology department , Faculty of Medicine , Beni-Suef University
3NILES , Beni-Suef University
4Faculty of medicine_Benisuef University
Abstract
The aim of this study was to detect changes in intraocular pressure(IOP) following initial intravitreal injection of antivascular endothelial growth factor agents anti-VEGF ranibizumab in patients presenting with macular edema due to diabetes mellitus (DM), age- related macular degeneration(ARMD) , retineal vein occlusion(RVO), and myopic choroidal neovascularization (CNV) .
Methods:In this study,a prospective analysis was conducted on 40 eyes of 40 patients. IOP was measured using a goldmann applanation tonometer before injection, 24 h, 1st and weekly up to 8 weeks after injection . Patients were scheduled for intravitreal injection of anti-VEGF ranibizumab (0.5 mg/0.05 ml) for the treatment of macular edema due to(DM), (RVO), (ARMD) ,and (CNV).
Results: It was fоund that there was a significant difference, but still within the normal range value in IOP measured 24 h after injection(14.2±3.54 mmHg and ranged from (9 : 22 mmHg)) compared to baseline (p = 0.001) . There was no significant difference between the IOP from 1 week up to 8W of ranibizumab injection.
Conclusion: This study confirms the results of previous studies that showed the safety of initial IV injection of anti-VEGF agents for IOP elevation in post-injection two monthes in non- glaucomatous patients.
Keywords
Intraocular; pressure; ranibizumab
References

1.Saif ATS, Saif PS , El Deeb A. Role of amniotic membrane transplantation in symblepharon. Guoji Yanke Zazhi(Int Eye Sci) 2017;17(5):819-824

2.Nassar M, Saif M, Saif A, Saif P. Sensitivity and specificity of nassar color test in early detection of diabetic macular edema. Journal of Retina-Vitreous. 2016;24:109-113.

3.Amer, S. , Saif, M. , Saif, A. and Saif, P. (2014) Variations of Cup-to-Disc Ratio in Children. Open Journal of Ophthalmology, 4, 12-17. doi: 10.4236/ojoph.2014.41003.

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