Synthesis , Spectral Characterization And Anticancer Studies of Novel Azo Schiff Base And its Complexes with Ag(I),Au(lll) And Pt(lV) ions | ||
| Egyptian Journal of Chemistry | ||
| Article 8, Volume 63, Issue 12, December 2020, Pages 4749-4756 PDF (1.59 M) | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/ejchem.2020.23312.2438 | ||
| Authors | ||
| shaimaa adnan* 1; Khalid J- Al-Adilee2; Khamis A-Abedalrazaq3 | ||
| 1university of Al-Qadisiyah | ||
| 2college of Education , university of Al-Qadisiyah | ||
| 3Universty of Al-Anbar | ||
| Abstract | ||
| A novel azo schiff base dye (L) has been Synthesized a reaction of 5- [ 2-(5-nitro thiazolyl)azo] -2-amino -4-methyl pyridine (NTAPy) with 4-chloro benzaldehyde in alkaline solution . Anew series of complexes with Ag(I) ,Au(III) and Pt(IV) ions was Prepared forming chelate complexes . The structure of azo schiff base ligand and its metal complexes were characterized by different spectral technique such as1H-NMR, 13C-NMR, mass spectrum , FT-IR, electronic Spectra , C-H.N.S analysis , magnetic susceptibility ,atomic absorption and molar conductivity .The analytical data suggests the mole ratio [ M:L] was [l:l] for Ag(I)and Au(III) ions but [l:2] for Pt(IV) ion. The metal complexes of Au(III) and pt (IV) was l:l and l:2 electrolyte receptivity while the Ag(I) complex is non electrolyte . In this study the cytoxicity of Ag(I), Au(III), and Pt (IV) complexes on humn (PC3) breast cancer and normal cells were MTT assay . | ||
| Keywords | ||
| Azo; schiff base; metal complexes and anticancer (breast cancer) | ||
|
Statistics Article View: 980 PDF Download: 1,025 |
||
