VALUE OF CEREBROSPINAL FLUID TUMOR NECROSIS FACTOR-ALPHA (TNF-ALPHA) FOR RAPID DIAGNOSIS OF BACTERIAL MENINGITIS
MONTASSER, I., EL-GINDY, E., ALLAM, E., ELBAZ, H., KHALIFA, R., ALI, H. (2015). VALUE OF CEREBROSPINAL FLUID TUMOR NECROSIS FACTOR-ALPHA (TNF-ALPHA) FOR RAPID DIAGNOSIS OF BACTERIAL MENINGITIS. EKB Journal Management System, 45(3), 655-662. doi: 10.21608/jesp.2015.97564
IMAN FAWZY MONTASSER; EMAN MOHAMED EL-GINDY; ENAS HASSAN ALLAM; HOSAM S. ELBAZ; REHAM ALI AHMED KHALIFA; HANY EL SAYED ALI. "VALUE OF CEREBROSPINAL FLUID TUMOR NECROSIS FACTOR-ALPHA (TNF-ALPHA) FOR RAPID DIAGNOSIS OF BACTERIAL MENINGITIS". EKB Journal Management System, 45, 3, 2015, 655-662. doi: 10.21608/jesp.2015.97564
MONTASSER, I., EL-GINDY, E., ALLAM, E., ELBAZ, H., KHALIFA, R., ALI, H. (2015). 'VALUE OF CEREBROSPINAL FLUID TUMOR NECROSIS FACTOR-ALPHA (TNF-ALPHA) FOR RAPID DIAGNOSIS OF BACTERIAL MENINGITIS', EKB Journal Management System, 45(3), pp. 655-662. doi: 10.21608/jesp.2015.97564
MONTASSER, I., EL-GINDY, E., ALLAM, E., ELBAZ, H., KHALIFA, R., ALI, H. VALUE OF CEREBROSPINAL FLUID TUMOR NECROSIS FACTOR-ALPHA (TNF-ALPHA) FOR RAPID DIAGNOSIS OF BACTERIAL MENINGITIS. EKB Journal Management System, 2015; 45(3): 655-662. doi: 10.21608/jesp.2015.97564

VALUE OF CEREBROSPINAL FLUID TUMOR NECROSIS FACTOR-ALPHA (TNF-ALPHA) FOR RAPID DIAGNOSIS OF BACTERIAL MENINGITIS

Journal of the Egyptian Society of Parasitology
Article 22, Volume 45, Issue 3, December 2015, Page 655-662  XML PDF (243.13 K)
Document Type: Original Article
DOI: 10.21608/jesp.2015.97564
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Authors
IMAN FAWZY MONTASSER1; EMAN MOHAMED EL-GINDY1; ENAS HASSAN ALLAM1; HOSAM S. ELBAZ2; REHAM ALI AHMED KHALIFA3; HANY EL SAYED ALI4
1Department of Tropical Medicine, Faculty of Medicine, Ain Shams University, Egypt.
2Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Egypt.
3Department of Microbiology and Immunology, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.
4Department of Embaba Fevers Hospital, Giza, Egypt.
Abstract
Meningitis is common in tropical areas and also in Egypt and has a world-wide distribution This study evaluated the potential role of CSF TNF α in diagnosis and differential diagnosis of acute meningitis (bacterial versus aseptic meningitis). This case-control study was conducted between Ain Shams University Tropical Medicine Department and Embaba Fever Hospital. Fifty patients with suspected meningitis were recruited during from January 2014 to June 2014. They were divided according to culture results into 2 groups: GI: 40 patients with acute bacterial meningitis (proved by CSF culture), G2: 10 patients matched according to age and sex with clinical sings of CNS infection but without laboratory evidence of bacterial origin, (Suspected cases, and negative culture). Both groups were subjected to thorough history taking, full clinical examination, and laboratory investigations including CSF analysis & CSF TNF was measured by ELISA. The results showed a highly significant difference between cases and control regarding CSF TNF (P=0.00). The criteria’s of diagnostic validity test was 100% for all at cutoff ≥275ng/ml and ≤700ng/ml with 100% specificity and sensitivity. A significant correlation between CSF-TNF and each of ESR (P=0.003) & CSF cells (P=0.015), without significant correlation regarding other parameters (P>0.05).
Keywords
Bacterial meningitis; aseptic meningitis; tumor necrosis factor
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